Overexpression of regucalcin supresses the growth of human osteosarcoma cells in vitro: Repressive effect of extracellular regucalcin.

Overexpression of regucalcin supresses the growth of human osteosarcoma cells in vitro: Repressive effect of extracellular regucalcin.
Cancer Invest. 2019 Dec 23;:1-40
Authors: Yamaguchi M, Murata T
Abstract
Regucalcin plays a pivotal role as a suppressor of human carcinogenesis, and downregulation of regucalcin expression may contribute to the promotion of human osteosarcoma. Overexpression of regucalcin suppressed the proliferation of Saos-2 human osteosarcoma cells in vitro and decreased the protein levels of multiple signaling components, transcription factors, and tumor suppressors. Interestingly, extracellular regucalcin repressed colony formation and proliferation of Saos-2 cells, and reduced the protein levels of multiple signaling components, cell cycle inhibitor, and various transcription factors. Thus, regucalcin suppressed the growth of human osteosarcoma cells, providing a novel strategy with the gene therapy for treatment of osteosarcoma.
PMID: 31868021 [PubMed - as supplied by publisher]

Source: Cancer Investigation - December 24, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research