Synthesis, structure and urease inhibition studies of Schiff base copper(II) complexes with planar four-coordinate copper(II) centers.

Synthesis, structure and urease inhibition studies of Schiff base copper(II) complexes with planar four-coordinate copper(II) centers.
J Inorg Biochem. 2013 Aug 2;127C:82-89
Authors: Dong X, Guo T, Li Y, Cui Y, Wang Q
Abstract
Seven new Schiff base copper(II) complexes with planar four-coordinate copper(II) centers have been synthesized and structurally characterized. The solid state structures of complexes 1, 3, 4, 5, 6 and 7 present a square-planar coordination geometry at the metal centers while complex 2 shows a slightly distorted square-planar geometry. Density functional theory calculations have been performed to evaluate the electronic structure of copper(II) complex 7. Inhibition of jack bean urease by copper(II) complexes 1-7 have also been investigated, and potent inhibitory activities with IC50 range of 2.60-17.00μM have been observed for these mononuclear copper(II) complexes. A docking analysis using a DOCK program was conducted to explain the urease inhibitory activity of the copper(II) complexes and the structure-activity relationships were further discussed.
PMID: 23962498 [PubMed - as supplied by publisher]

Source: Journal of Inorganic Biochemistry - August 2, 2013 Category: Biochemistry Authors: Dong X, Guo T, Li Y, Cui Y, Wang Q Tags: J Inorg Biochem Source Type: research