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A bigger fish for palaeontogists to fry…

A chance find in a quarry led to the discovery that Leedsichthys problematicus grew up to 50ft long – double previous estimatesAn international team of scientists has uncovered the remains of the world's largest fish. The 50ft Leedsichthys problematicus swam the oceans of the Jurassic era more than 160m years ago, sweeping up shoals of plankton through giant, mesh-covered gills. Leedsichthys was eventually wiped out by the same catastrophe that killed the dinosaurs 66m years ago.The discovery by the team – led by Professor Jeff Liston of the National Museums of Scotland – is intriguing because it reveals that just as dinosaurs on land were going through major changes which saw the appearance of animals of vast dimensions – creatures that included Diplodocus, Apatosaurus and Brachiosaurus – reptiles in the sea had also started to grow to vast proportions in the Jurassic."The process is known as gigantism," said Liston. "It was known about in land animals at the time but we had no way of knowing if a parallel process occurred in the oceans. We now know that it did – though the reason for appearance of these gigantic beasts, both on land and in the water, is not clear at present."Pieces of Leedsichthys fossils were first found by the British collector Alfred Leeds in 1889. Similar remains were subsequently found at other sites, from northern Germany to Normandy, Mexico and the Atacama desert in Chile. However, knowledge of ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Evolution Dinosaurs Editorial The Observer Fossils Zoology Science Source Type: news

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AbstractA heterogeneous group of epithelial cystic tumors developed at the infundibulum and the third ventricle disconcerted pathologists at the dawn of the twentieth century. Very little was known at that time about the physiological role played by the pituitary gland, and there was almost complete ignorance regarding the function of the hypothalamus. Acromegaly, or enlargement of acral body parts, described in 1886 by Pierre Marie, was the only disease linked to primary hypertrophies of the pituitary gland, known as “pituitary strumas”. A growing number of young patients manifesting an unexplained combination...
Source: Pituitary - Category: Endocrinology Source Type: research
Clinical Endocrinology, EarlyView.
Source: Clinical Endocrinology - Category: Endocrinology Authors: Source Type: research
KIP SULLIVAN Lawton Burns and Mark Pauly, economists at the Wharton School, just published an article that should be required reading for all policy makers and health services researchers. The article,  entitled “Transformation of the health care industry: Curb your enthusiasm,” appears in the latest edition of the Milbank Quarterly. Burns and Pauly undertook an enormous task and executed it well. They first sought to explain the assumptions underlying Managed Care (MC) 2.0 – the proposals promoted by the managed care movement in the wake of the HMO backlash of the late 1990s. Then they evaluat...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: blogs
Publication date: Available online 17 March 2018 Source:Best Practice & Research Clinical Endocrinology & Metabolism Author(s): Giampaolo Trivellin, Laura C. Hernández-Ramírez, Jeremy Swan, Constantine A. Stratakis X-linked acrogigantism (X-LAG) is a recently described form of familial or sporadic pituitary gigantism characterized by very early onset GH and IGF-1 excess, accelerated growth velocity, gigantism and/or acromegaloid features. Germline or somatic microduplications of the Xq26.3 chromosomal region, invariably involving the GPR101 gene, constitute the genetic defect leading to X-LAG. G...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
ConclusionThe technique presented herein effectively improved the quality of life of patients with acromegaly with different levels of disease activity, type, and treatment time.
Source: Pituitary - Category: Endocrinology Source Type: research
In this study, we aimed to evaluate the presence of glucose metabolism abnormalities and their impact on IGF-1 levels in patients with acromegaly. Ninety-three patients with acromegaly (n=93; 52 males/41 females) were included in this study. Patients were separated into three groups such as; normal glucose tolerance (n=23, 25%), prediabetes (n=38, 41%), and diabetes mellitus (n=32, 34%). Insulin resistance was calculated with homeostasis model assessment (HOMA). HOMA-IR> 2.5 or ≤2.5 were defined as insulin resistant or noninsulin resistant groups, respectively. Groups were compared in terms of factors that may...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Tags: Endocrine Care Source Type: research
ConclusionsOur data demonstrate a low prevalence of acromegaly in patients with OSAS. Until data from population-based studies is available we suggest restricting screening for acromegaly in OSAS to those patients who have additional clinical features of acromegaly.
Source: Endocrine - Category: Endocrinology Source Type: research
AbstractBackgroundTranssphenoidal surgery (TSS) is the cornerstone of acromegaly treatment, however there are no robust predictors of surgical outcome and remission can only be defined three months after surgery.PurposeTo analyze if biochemical, demographical, radiological, and immunohistochemical characteristics are predictors of surgical remission and investigate if immediate postoperative GH and IGF-I levels can help defining remission earlier.MethodsConsecutive acromegaly patients submitted to TSS between 2013-2016 were evaluated. Remission criteria was defined as normal IGF-I and GH
Source: Endocrine - Category: Endocrinology Source Type: research
Clinical Endocrinology, EarlyView.
Source: Clinical Endocrinology - Category: Endocrinology Authors: Source Type: research
Source: Notes from Dr. RW - Category: Internal Medicine Tags: cardiovascular endocrinology Source Type: blogs
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