A bigger fish for palaeontogists to fry…

A chance find in a quarry led to the discovery that Leedsichthys problematicus grew up to 50ft long – double previous estimatesAn international team of scientists has uncovered the remains of the world's largest fish. The 50ft Leedsichthys problematicus swam the oceans of the Jurassic era more than 160m years ago, sweeping up shoals of plankton through giant, mesh-covered gills. Leedsichthys was eventually wiped out by the same catastrophe that killed the dinosaurs 66m years ago.The discovery by the team – led by Professor Jeff Liston of the National Museums of Scotland – is intriguing because it reveals that just as dinosaurs on land were going through major changes which saw the appearance of animals of vast dimensions – creatures that included Diplodocus, Apatosaurus and Brachiosaurus – reptiles in the sea had also started to grow to vast proportions in the Jurassic."The process is known as gigantism," said Liston. "It was known about in land animals at the time but we had no way of knowing if a parallel process occurred in the oceans. We now know that it did – though the reason for appearance of these gigantic beasts, both on land and in the water, is not clear at present."Pieces of Leedsichthys fossils were first found by the British collector Alfred Leeds in 1889. Similar remains were subsequently found at other sites, from northern Germany to Normandy, Mexico and the Atacama desert in Chile. However, knowledge of ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Evolution Dinosaurs Editorial The Observer Fossils Zoology Science Source Type: news

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Authors: Mercado M, Ramírez-Rentería C Abstract Diabetes is recognized as one of the most common acromegaly co-morbidities with a prevalence ranging 20-53%, while over one-third of these patients have an altered lipid profile. In fact, as in the non-acromegalic population, carbohydrate and lipid metabolism abnormalities are closely linked. Long term exposure to an excess of growth hormone (GH) and Insulin-like growth factor-1 concentrations results in insulin resistance and an increased hepatic glucose production. The lipolytic effect of GH results in the mobilization of free fatty acids that further ...
Source: Frontiers of Hormone Research - Category: Endocrinology Tags: Front Horm Res Source Type: research
Source: Endocrine - Category: Endocrinology Source Type: research
The objective of this study was to investigate the effect of hyperprolactinemia and high levels of insulin-like growth factor-I (IGF-I) on bone resorption and their relation with receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) in patients with prolactinoma and acromegaly. Thirty-one patients with acromegaly, 28 patients with prolactinoma, and 33 healthy individuals were included in the study. Serum concentrations of RANKL, OPG, bone alkaline phosphatase (bone ALP), osteocalcin (OC), C-terminal telopeptide of type 1 collagen (CTX), procollagen type 1 N-terminal propeptide (P1NP)...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Tags: Endocrine Care Source Type: research
J. A. Goldbogen and P. T. Madsen The extant diversity and rich fossil record of cetaceans provides an extraordinary evolutionary context for investigating the relationship between form, function and ecology. The transition from terrestrial to marine ecosystems is associated with a complex suite of morphological and physiological adaptations that were required for a fully aquatic mammalian life history. Two specific functional innovations that characterize the two great clades of cetaceans, echolocation in toothed whales (Odontoceti) and filter feeding in baleen whales (Mysticeti), provide a powerful comparative framework ...
Source: Journal of Experimental Biology - Category: Biology Authors: Tags: COMMENTARY Source Type: research
Conclusions Excessive growth hormone secretion persisting after pituitary surgery and irradiation can be controlled in a convenient way for the patient with acromegaly by combining monthly lanreotide and weekly pegvisomant injections, if monotherapy with a somatostatin analog fails. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Experimental and Clinical Endocrinology and Diabetes Reports - Category: Endocrinology Authors: Tags: Case Report Source Type: research
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0629-9223 Purpose Prevalence of papillary thyroid cancer (PTC) is increased in patients with acromegaly. We aimed to determine the protein expression of BRAF, RAS, RET, insulin like growth factor 1(IGF1), Galectine 3, CD56 in patients with PTC related acromegaly and to compare the extensity of these expressions with normal PTC patients and benign thyroid nodules. Methods We studied 313 patients with acromegaly followed in Cerrahpasa Medical Faculty, Endocrinology and Metabolism Clinic between 1998 and 2015. On the basis of availability of pathological specimen of thyroid tissues,...
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research
Condition:   Acromegaly Interventions:   Drug: IONIS-GHR-LRx;   Drug: Placebo Sponsor:   Ionis Pharmaceuticals, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Shen M, Wang M, He W, He M, Qiao N, Ma Z, Ye Z, Zhang Q, Zhang Y, Yang Y, Cai Y, ABuDuoReYiMu Y, Lu Y, Lu B, Shou X, Wang Y, Ye H, Li Y, Li S, Zhao Y, Cao X, Zhang Z Abstract Purpose: To evaluate the change in glucose tolerance in treatment-naïve patients with acromegaly after administration of SSA and to identify predictive factors of glucose impairment during SSA therapy. Methods: Oral glucose tolerance testing (OGTT) was performed on 64 newly diagnosed and treatment-naïve patients with acromegaly both at pretreatment and 3 months after initiation of treatment with long-acting SSA. Insulin ...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
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