Hepatitis gene therapy leads Bay Area trio of year-end FDA approval requests

Approaching the end of long drug-development journeys, these three Bay Area companies formally asked the FDA to approve potential treatments for hemophilia A, anemia in chronic kidney disease patients and migraines.
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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UPDATE OF LIVER TRANSPLANTATION - NEWER ASPECTS. Turk J Med Sci. 2020 Mar 28;: Authors: Metin RO, Şimşek C, Gürakar AÖ Abstract Liver transplantation (LT) remainsas the only therapeutic option offering gold standard treatment for end-stage liver disease (ESLD) and acute liver failure (ALF), as well as for certain early-stage liver tumors. Currently, the greatest challenge facing LT is the simple fact that there are not adequate livers for all the potential patients that could benefit from LT. Despite efforts to expandthe donor pool to include the living and deceased donors, organ shortage i...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
This study investigated differences between episodic and chronic cluster headache with a focus on family history, traumatic history, and change in phenotype. Do these factors differ between subtypes?Headache
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news
What have we learned about optimizing cardiorenal protection in advanced CKD from landmark papers published in 2018?Nephrology Dialysis Transplantation
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news
A 43 ‐year‐old man who was treated with interferon‐beta for multiple sclerosis was presented with hypertension, headache, nausea/vomiting, blurred vision, and renal dysfunction. The treatment with drugs and dialysis relieved the symptoms. Despite plasmapheresis is known to cause improvement in rena l function, no such improvement was seen in patient. AbstractA 43 ‐year‐old man who was treated with interferon‐beta for multiple sclerosis was presented with hypertension, headache, nausea/vomiting, blurred vision, and renal dysfunction. The treatment with drugs and dialysis relieved the symptoms. Despite plasmapher...
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
AbstractEptinezumab is a humanized mAb that targets calcitonin gene ‐related peptide and is under regulatory review for the prevention of episodic and chronic migraine (EM, CM). It is important to determine whether exposures achieved with intravenous (IV) administration of eptinezumab achieve desired pharmacologic effects. Population pharmacokinetics, including do se‐ and exposure‐response analyses, were performed using patient‐level data from the eptinezumab clinical trial program with IV doses ranging from 10 to 1000 mg in pharmacokinetic analyses or 10 to 300 mg in phase 2/3 clinical studies in patient...
Source: Pharmacology Research and Perspectives - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusion: The relatively high prevalence of symptoms of the cervical spine dysfunction, chronic pain, stress, and neck disability among young people may indicate that numerous spinal disorders identified in dentists result not only from their profession, in which spine is significantly overloaded, but also individual predispositions including biopsychosocial profile and the changing lifestyle habits of young people.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Circulating androgens prime the kidney for fibrosis upon infectious injury (Escherichia coli pyelonephritis) by enhancing local TGF β1 production and myofibroblast activation. AbstractRenal scarring after pyelonephritis is linked to long ‐term health risks for hypertension and chronic kidney disease. Androgen exposure increases susceptibility to, and severity of, uropathogenicEscherichia coli (UPEC) pyelonephritis and resultant scarring in both male and female mice, while anti ‐androgen therapy is protective against severe urinary tract infection (UTI) in these models. This work employed androgenized female C57BL/...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
On her run, she finished a six-mile loop with no trouble, but she felt a little off: a bit of chest tightness, a headache. Was this coronavirus?
Source: NYT Health - Category: Consumer Health News Authors: Tags: Coronavirus (2019-nCoV) Tests (Medical) Hospitals Coughs Doctors United States Source Type: news
 Nefertiti Brown, MD's life is on pause right now. The 39-year-old physician is quarantined in her home, awaiting results from a COVID-19 test she took nearly two weeks ago. Dr. Brown, a graduate of the University of Pittsburgh School of Medicine, is an attending physician in the Bay area. Dr. Brown spoke with MD+DI on Saturday about her experience and how she hopes it can make an impact on others. “Shortly after daylight savings time, I noticed that I was feeling tired,” the New York native recounted. “But I’m always tired. Iâ€&...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news
(HAMBURG, Pa.) — The spring breezes of 2020 are carrying more than just tree pollen. There’s a whiff of paranoia in the air. For millions of seasonal allergy sufferers, the annual onset of watery eyes and scratchy throats is bumping up against the global spread of a new virus that produces its own constellation of respiratory symptoms. Forecasters are predicting a brutal spring allergy season for swaths of the U.S. at the same time that COVID-19 cases are rising dramatically. That’s causing angst for people who never have had to particularly worry about their hay fever, other than to stock up on antihista...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 News Desk wire Source Type: news
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