The role of gene conversion in preserving rearrangement hotspots in the human genome.

The role of gene conversion in preserving rearrangement hotspots in the human genome.
Trends Genet. 2013 Aug 13;
Authors: Fawcett JA, Innan H
Abstract
Hotspots of non-allelic homologous recombination (NAHR) have a crucial role in creating genetic diversity and are also associated with dozens of genomic disorders. Recent studies suggest that many human NAHR hotspots have been preserved throughout the evolution of primates. NAHR hotspots are likely to remain active as long as the segmental duplications (SDs) promoting NAHR retain sufficient similarity. Here, we propose an evolutionary model of SDs that incorporates the effect of gene conversion and compare it with a null model that assumes SDs evolve independently without gene conversion. The gene conversion model predicts a much longer lifespan of NAHR hotspots compared with the null model. We show that the literature on copy number variants (CNVs) and genomic disorders, and also the results of additional analysis of CNVs, are all more consistent with the gene conversion model.
PMID: 23953668 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - August 13, 2013 Category: Genetics & Stem Cells Authors: Fawcett JA, Innan H Tags: Trends Genet Source Type: research