The efficacy of perampanel in young children with drug-resistant epilepsy

Epilepsy is the most common neurological disorder in children. The prevalence of epilepsy ranges from 3 to 5 per 1000 children in developed countries, and the incidence is about 41 to 187/100,000 person-years [1]. Previous studies have shown the incidence of epilepsy to be highest in the first year of life, ranging from 81 to 130/100,000 [1]. Of those with epilepsy, about 10% of children have drug-resistant epilepsy [2]. The common etiologies of drug-resistant epilepsy can be very diverse, including epilepsy syndromes (e.g., West syndrome and Lennox –Gastaut syndrome), genetic epilepsy (like tuberous sclerosis, TSC), structural causes (e.g., cortical dysplasia or mesial temporal sclerosis), and miscellaneous origins (e.g., connective tissue disorders, autoimmune epilepsies) [3].
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research