DLBCL after Allogeneic HCT in a Patient with Transformed DLBCL: Does it matter Whether Relapse or PTLD?

Posttransplant lymphoproliferative disorder (PTLD), comprising a wide spectrum of lymphoid and plasmacytic proliferation, is a potentially fatal disorder arising after solid organ transplant (SOT) or hematopoietic stem cell transplant (HCT). The incidence of PTLD ranges from 0.07% (autologous) to as high as 29% (T cell depleted match unrelated donor) after HCT and is associated with Epstein-Barr virus (EBV) infection. 1,2 Impaired immune surveillance and pharmacologic immunosuppression are key factors in the pathogenies.

Source: Clinical Lymphoma, Myeloma and Leukemia - December 22, 2019 Category: Hematology Authors: Sunita Nathan, Mohammad Junaid Hussain, Jacqueline Baptista, Hyun Don Yun, Ankur Varma, Alexandra Vardouniotis, Mallory Weber, Ira Miller, Celalettin Ustun. Tags: Letter to the Editor Source Type: research