Insulin ‐derived amyloidosis without a palpable mass at the insulin injection site: A report of two cases

This report presents two cases of insulin‐derived amyloidosis without palpable masses at insulin injection sites. In both cases, blood glucose concentrations improved, and the insulin dose could be reduced by an average of 45% after changing the insulin injection sites. The insulin absorption at the site was reduced to at most 40% of that at a normal site in one case. Magnetic resonance imaging and ultrasonography were useful to screen and differentiate insulin‐derived amyloido sis without a palpable mass. This report showed that insulin‐derived amyloidosis without a palpable mass can be present at the insulin injection site and has similar clinical effects to insulin‐derived amyloidosis with palpable masses.

Source: Journal of Diabetes Investigation - December 21, 2019 Category: Endocrinology Authors: Terumasa Nagase, Keiichi Iwaya, Koichiro Kogure, Tamotsu Zako, Yohei Misumi, Minoru Kikuchi, Koichi Matsumoto, Masayuki Noritake, Yasuhiro Kawachi, Masaki Kobayashi, Yukio Ando, Yoshiya Katsura Tags: CASE REPORT Source Type: research