Aspirin antiplatelet effects are associated with body weight.

CONCLUSION: Insufficient pharmacodynamic response to aspirin is associated with body weight. This finding may play a role in the impaired clinical efficacy of aspirin in patients >70 kg. An optimal aspirin regime in these patients needs to be evaluated in large scale trials.
PMID: 31862488 [PubMed - as supplied by publisher]

Source: Vascular Pharmacology - December 16, 2019 Category: Drugs & Pharmacology Authors: Mourikis P, Zako S, Dannenberg L, Helten C, Naguib D, Hohlfeld T, Petzold T, Levkau B, Zeus T, Kelm M, Polzin A Tags: Vascul Pharmacol Source Type: research