Titration of Igs contained in an intravenous IgM-enriched preparation against selected pathogens involved in sepsis.

Titration of Igs contained in an intravenous IgM-enriched preparation against selected pathogens involved in sepsis. Immunobiology. 2019 Dec 14;:151897 Authors: Stracquadanio S, Lo Verde F, Cialfi A, Zega A, Stefani S, Cafiso V Abstract The goal of our work was to titer the IgG, IgM and IgA in Pentaglobin® (a preparation enriched in IgM), targeting specific surface antigens of Gram-positive and Gram-negative bacteria as well as a C. albicans strain. Lipopolysaccharides from Gram-negative bacteria, peptidoglycan and lipoteichoic acid from the other microorganisms were extracted and used in several ELISA assays in order to determine the titration of immunoglobulins in Pentaglobin® directed towards the aforementioned surface antigens. Our results showed an overall immunoglobulin titer of at least 103 in Pentaglobin® with some exceptions for the IgA titers and for some immunoglobulin titers against E. faecalis, K. pneumoniae and P. aeruginosa. According to these results, Pentaglobin® can be considered as a potential adjuvant for antimicrobial therapy. PMID: 31864730 [PubMed - as supplied by publisher]
Source: Immunobiology - Category: Allergy & Immunology Authors: Tags: Immunobiology Source Type: research