BONNIE ESTRIDGE on life with Alzheimer's: They've banned me from the kitchen… and I'm delighted!

BONNIE ESTRIDGE: This year the girls are coming over for Christmas Day, and my husband Chris will work his magic with a small turkey. Seeing them is what it's all about for me.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

Related Links:

The Alzheimer's disease research community is nowadays ever more strongly considering chronic inflammation in the brain as a vital part of the progression of the condition. In the amyloid cascade hypothesis, a slow aggregation of amyloid-β over decades (for reasons that are debated) causes ever greater inflammatory dysfunction in microglia, the immune cells of the brain responsible for clearing up metabolic waste such as protein aggregates. That inflammation in turn sets the stage for tau aggregation to take place to a significant degree, causing cell death and severe neural dysfunction. Today's open access res...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Condition:   Alzheimer Disease With Major Neurocognitive Disorder Intervention:   Procedure: Music Therapy Sponsor:   Centre Hospitalier Universitaire de Nice Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Funding Opportunity PAR-20-156 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) enables data-driven drug repositioning and combination therapy for Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) by developing computational methods and data resources and/or integrating computational approaches with proof-of-concept efficacy studies in cell-based models, animal models, and/or humans.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Funding Opportunity PAR-20-157 from the NIH Guide for Grants and Contracts. The goal of this Funding Opportunity Announcement (FOA) is to encourage applications for studies that will enhance knowledge of mechanisms associated with neuropsychiatric symptoms (NPS) in persons with Alzheimer's disease (AD) or Alzheimer's disease-related dementias (ADRD). The findings are expected to advance mechanistic understanding of both biobehavioral and neurobiological pathways leading to NPS. Findings may also provide insight into novel therapeutic targets that can be advanced into interventions to treat and prevent the development of NPS in AD and/or ADRD
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Funding Opportunity PAR-20-159 from the NIH Guide for Grants and Contracts. The goal of this Funding Opportunity Announcement (FOA) is to encourage applications for studies that will enhance knowledge of mechanisms associated with neuropsychiatric symptoms (NPS) in persons with Alzheimer's disease (AD) or Alzheimer's disease-related dementias (ADRD). The findings are expected to advanceadavnce mechanistic understanding of both biobehavioral and neurobiologfical pathways leading to NPS. Findings may also provide insight into novel therapeutic targets that can be advanced into interventions to treat and prevent the developm...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
The brains of Alzheimer's Disease patients show a decrease in brain mass and a preponderance of extracellular Amyloid- β plaques. These plaques are formed by aggregation of polypeptides that are derived from the Amyloid Precursor Protein (APP). Amyloid-β plaques are thought to play either a direct or an indirect role in disease progression, however the exact role of aggregation and plaque formation in the aetiolog y of Alzheimer's Disease is subject to debate as the biological effects of soluble and aggregated Amyloid-β peptides are difficult to separatein vivo. To investigate the consequences of formation o...
Source: eLife - Category: Biomedical Science Tags: Developmental Biology Neuroscience Source Type: research
Human neurodegenerative diseases, such as Alzheimer’s disease (AD), are not easily modeled in vitro due to the inaccessibility of brain tissue and the level of complexity required by existing cell culture systems. Three-dimensional (3D) brain organoid systems generated from human pluripotent stem cells (hPSCs) have demonstrated considerable potential in recapitulating key features of AD pathophysiology, such as amyloid plaque- and neurofibrillary tangle-like structures. A number of AD brain organoid models have also been used as platforms to assess the efficacy of pharmacological agents in disease progression. Howeve...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and represents one of the earliest pathomechanistic alterations throughout the AD continuum. Large-scale genome-wide association studies point out several genetic variants—TREM2, CD33, PILRA, CR1, MS4A, CLU, ABCA7, EPHA1, and HLA-DRB5-HLA-DRB1—potentially linked to neuroinflammation. Most of these genes are involved in proinflammatory intracellular signaling, cytokines/interleukins/cell turnover, synaptic activity, lipid metabolism, and vesicle trafficking. Proteomic studies indicate that a plethora of interconnected aberrant mol...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Nature Reviews Neurology, Published online: 31 March 2020; doi:10.1038/s41582-020-0353-3Mitochondrial dysfunction manifests in the early stages of Alzheimer disease
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
A team of scientists, based at Swiss Federal Institute of Technology Lausanne (EPFL) with collaborators at Ulm University in Germany, University of Modena and Reggio Emilia in Italy, and MIT, have developed custom nanoparticles for high-resolution de...
Source: Medgadget - Category: Medical Devices Authors: Tags: Materials Medicine Nanomedicine Neurology Neurosurgery Radiology Source Type: blogs
More News: Alzheimer's | Girls | Health | Middle East Health | Turkey Health