Dentate nNOS accounts for stress-induced 5-HT1A receptor deficiency: Implication in anxiety behaviors.

CONCLUSIONS: These findings uncovered an important role of nNOS-5-HT1A receptor pathway in the DG of the hippocampus in chronic stress-induced anxiety. Accordingly, we developed a "dentate nNOS-5-HT1A receptor closed-loop" theory (stress-glucocorticoids-nNOS-Nitric oxide-ONOO•-5-HT1A receptor -nNOS) of stress-related anxiety. PMID: 31863649 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31863649?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - December 20, 2019 Category: Neuroscience Authors: Zhu LJ, Xu C, Ren J, Chang L, Zhu XH, Sun N, Meng GL, Liu MY, Zhang J, Li YY, Tang YL, Zhou QG Tags: CNS Neurosci Ther Source Type: research