Human umbilical endothelial cells (HUVECs) have a sex: characterisation of the phenotype of male and female cells

Conclusions The results indicate that sex differences exist in prenatal life and are parameter-specific, suggesting that HUVECs of both sexes should be used as an in vitro model to increase the quality and the translational value of research. The sex differences observed in HUVECs could be relevant in explaining the diseases of adulthood because endothelial dysfunction has a crucial role in the pathogenesis of cardiovascular diseases, diabetes mellitus, neurodegeneration and immune disease.
Source: Biology of Sex Differences - Category: Biology Source Type: research