'The day I found out that I will likely outlive my children'

Sharon Stepaniuk learned on the same day her oldest and youngest have cystic fibrosis. She hopes she can make a difference for them, and for others in Canada living with CF.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/Edmonton Source Type: news

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SYMDEKO is a drug for the treatment of cystic fibrosis (CF) in patients 12 years and older, who have specific gene mutations
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
Biofilms usually occur on or within medical devices such as mechanical heart valves, prosthetic joints, peritoneal dialysis catheters, contact lenses, central venous catheters, pacemakers and urinary catheters. The presence of biofilms can be seen in different diseases like endocarditis, otitis, cystic fibrosis, periodontitis, osteomyelitis and chronic wounds. Toxin–antitoxin systems are reported to respond to stresses that are also found in the host. Some toxins of toxin–antitoxin systems modules have been proposed as potential weapons used by bacteria to act on host targets. In this review, we focus on the mo...
Source: Reviews in Medical Microbiology - Category: Microbiology Tags: BACTERIOLOGY Source Type: research
Basic and clinical sciences inform and transform the ways in which we practice medicine at the bedside. As our scientific understanding evolves at an accelerating rate, we are also witnessing an evolution in publication practices. As Editors of JCF, we feel it is timely to revisit some of the trends, challenges and opportunities facing publication practices. In this Editorial, we compile a list of key publishing issues that we feel will shape how we move forward, both as an active publishing Journal, but also as a broader scientific community.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Editorial Source Type: research
ConclusionsHigh intensity interval training increases cardiorespiratory fitness and exercise capacity when compared with no exercise and produces a similar magnitude of change as continuous exercise in people with COPD. There is a paucity of studies exploring the effects of HIIT in other chronic pulmonary conditions.
Source: BMC Sports Science, Medicine and Rehabilitation - Category: Sports Medicine Source Type: research
(CF) is the most common autosomal recessive condition to affect white individuals. Defects in the CFTR chloride channel result in progressive organ dysfunction, particularly affecting the respiratory system. Patients require life-long care from multidisciplinary teams in specialist centres. Over time, improvements in screening and understanding of pathogenic alleles have increased diagnosis, while advances in management have led to better survival. The recent emergence of CFTR-modulating agents offers the potential to stabilize and improve lung disease, nutrition and quality of life in many people with CF.
Source: Medicine - Category: Internal Medicine Authors: Tags: Cystic fibrosis Source Type: research
Aspergillus spp. is a ubiquitous mold found commonly in our environment that can cause a spectrum of pulmonary disorders ranging from a hypersensitivity reaction to an acutely invasive disease with significant mortality. Allergic bronchopulmonary aspergillosis results from airway hypersensitivity from aspergillus colonization almost exclusively in patients with asthma and cystic fibrosis. Chronic pulmonary aspergillosis typically present in immunocompetent patients with underlying lung pathology.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Review Source Type: research
Publication date: Available online 28 March 2020Source: Food Research InternationalAuthor(s): Joaquim Calvo-Lerma, Andrea Asensio-Grau, Ana Heredia, Ana Andrés
Source: Food Research International - Category: Food Science Source Type: research
Bronchiectasis is a complex, chronic respiratory condition, characterized by frequent cough and exertional dyspnea due to a range of conditions that include inherited mucociliary defects, inhalational airway injury, immunodeficiency states and prior respiratory infections. For years, bronchiectasis was classified as either being caused by cystic fibrosis or non-cystic fibrosis. Non-cystic fibrosis bronchiectasis, once considered an orphan disease, is more prevalent worldwide in part due to greater availability of chest computed tomographic imaging.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Tags: Review article Source Type: research
Publication date: April 2020Source: Stem Cell Research, Volume 44Author(s): Sylvia Merkert, Madline Schubert, Alexandra Haase, Hettie M. Janssens, Bob Scholte, Nico Lachmann, Gudrun Göhring, Ulrich Martin
Source: Stem Cell Research - Category: Stem Cells Source Type: research
L. Sinn Extracellular vesicles (EVs) are a class of naturally occurring secreted cellular bodies that are involved in long distance cell-to-cell communication. Proteins, lipids, mRNA, and miRNA can be packaged into these vesicles and released from the cell. This information is then delivered to target cells. Since EVs are naturally adapted molecular messengers, they have emerged as an innovative, inexpensive, and robust method to deliver therapeutic cargo in vitro and in vivo. Well-differentiated primary cultures of human airway epithelial cells (HAE) are refractory to standard transfection techniques. Indeed, common s...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
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