The Guardian view on high-end science in the National Health Service

The genome project and improving ambulance response times both matterThe NHS has an extraordinary record of medical innovation. The link between smoking and lung cancer, the first baby born through IVF and the first heart, lung and liver transplant were all achievements of the health service. Now the 11 hospital trusts which will pioneer the 100,000 genome project have been named. They will recruit participants in an ambitious attempt to sequence the genetic make-up of up to 100,000 NHS patients, creating a database to allow researchers to identify the links between genetic variations and cancers and other rare diseases. At last the high hopes of gene sequencing may be translated into practical medicine. There is talk of genetics as a diagnostic tool, the development of personalised medicine and new, precision-targeted drugs that would amount to a revolution in healthcare. As the health secretary, Jeremy Hunt, argued in a speech last month, the NHS is remarkably good at advanced medical science.This tradition of medical creativity sits awkwardly with the other image of the NHS, as a sclerotic organisation that is as bad at delivering new ways of managing process as it is good at bringing in new ways of treating people. This may not be fair. Restraining the cost of healthcare is a global preoccupation, and the NHS delivers better outcomes for less money than any other comparable system. All the same, the unique politics of the NHS can lead to damaging contortions, as the weeke...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: NHS Health Society Medical research Science Source Type: news

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James Salaz (left), of Montrose, Colorado, was diagnosed with a rare form of cancer in 2012 by Dr Choon-Kee Lee (right). After five years, Salaz learned he actually had blood vessel inflammation.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 14 November 2018Source: The American Journal of SurgeryAuthor(s): Erica Burkheimer, Leah Starks, Mariam Khan, Leon Oostendorp, Marianne K. Melnik, Mathew H. Chung, G. Paul WrightAbstractIntroductionObesity has been associated with negative oncologic outcomes in breast cancer.MethodsRetrospective review of patients with operable breast cancer at a single institution from 2009–2012. Patients with carcinoma in situ or metastatic disease were excluded. Variables included utilization of MRI, surgical treatment, perioperative, and long-term oncologic outcomes. Primary outcome was rate of ...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionsSeveral factors are associated with a non-complete mesorectal excision. Non-complete mesorectal grade is associated with decreased survival.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 14 November 2018Source: European Journal of RadiologyAuthor(s): Alireza Aminsharifi, Rajan T. Gupta, Efrat Tsivian, Sitharthan Sekar, Christina Sze, Thomas J. PolascikAbstractPurposeTo introduce and assess the efficacy of a reduced core targeted (RCT) biopsy template (image-targeted + laterally directed sextant biopsy) to detect clinically-significant cancer in patients with elevated PSA and a previous negative biopsy or on active surveillance. The performance and added value of either targeted alone vs random sextant vs combined biopsy template was appraised.MethodsData fro...
Source: European Journal of Radiology - Category: Radiology Source Type: research
We report a case of a patient transplanted 13  years ago for NET metastases, with a lesion histologically proved for NET metastasis located at the cava vein anastomosis. He was treated with percutaneous radiofrequency ablation (RFA) after a first failed attempt of endovascular approach. The vascular heat sink, which RFA is susceptible to, was considered an advantage in this case, since it restricted the propagation of heat only to the tissue located in the very proximity of the RFA antenna, protecting the inferior vena cava vessel walls. This positive result may suggest an additional use of RFA in selected challenging cases.
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
AbstractPurposeWe aimed to validate the performance of the hepatitis B-based Hong Kong Liver Cancer (HKLC) staging system compared with the Barcelona Clinic Liver Cancer (BCLC) staging system in Chinese hepatocellular carcinoma (HCC) patients treated with conventional transarterial chemoembolization (TACE) as the initial treatment.Materials and MethodsThe study was approved by the Institutional Review Boards at all participating centers. This retrospective study included 715 patients with HCC who underwent TACE as the initial treatment between January 2008 and December 2016 at three Chinese institutions. All of the patient...
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
AbstractOne area which has emerged as an important factor for predicting molecular profile and treatment outcomes in metastatic colorectal cancer (mCRC) is primary tumor location. The importance of molecular characteristics of colorectal cancer has been firmly established in terms of prognosis and treatment algorithms for many years. Recent studies have also suggested that molecular profiles are important in locoregional therapies as well, with some data suggesting changes in treatment algorithms based on tumor location. Therefore, it is important for interventional radiologists to understand the basic molecular characteri...
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
Thursday is pancreatic awareness day.
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
In a move that will expand research and clinical trials, Roswell Park Comprehensive Cancer Center has announced a new academic agreement with one of Europe ’s oldest educational institutions. The collaboration with the Jagiellonian University (JU) in Kraków, Poland, will include exchanges of staff, students and scientific resources to advance the development of cancer therapies for patients worldwide. Effective immediately, the deal could see excha nge of students and faculty between the two centers…
Source: Health Care News Headlines - Category: Health Management Authors: Source Type: news
CONCLUSIONS High-level expression of KIF22 was related to both tumor progression and adverse clinical outcome. For this reason, KIF22 may become a potential prognostic factor for PCa. PMID: 30427826 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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