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The Guardian view on high-end science in the National Health Service

The genome project and improving ambulance response times both matterThe NHS has an extraordinary record of medical innovation. The link between smoking and lung cancer, the first baby born through IVF and the first heart, lung and liver transplant were all achievements of the health service. Now the 11 hospital trusts which will pioneer the 100,000 genome project have been named. They will recruit participants in an ambitious attempt to sequence the genetic make-up of up to 100,000 NHS patients, creating a database to allow researchers to identify the links between genetic variations and cancers and other rare diseases. At last the high hopes of gene sequencing may be translated into practical medicine. There is talk of genetics as a diagnostic tool, the development of personalised medicine and new, precision-targeted drugs that would amount to a revolution in healthcare. As the health secretary, Jeremy Hunt, argued in a speech last month, the NHS is remarkably good at advanced medical science.This tradition of medical creativity sits awkwardly with the other image of the NHS, as a sclerotic organisation that is as bad at delivering new ways of managing process as it is good at bringing in new ways of treating people. This may not be fair. Restraining the cost of healthcare is a global preoccupation, and the NHS delivers better outcomes for less money than any other comparable system. All the same, the unique politics of the NHS can lead to damaging contortions, as the weeke...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: NHS Health Society Medical research Science Source Type: news

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Authors: Sawicka-Żukowska M, Krawczuk-Rybak M, Bernatowicz P, Muszyńska-Rosłan K, Konstantynowicz J, Łuczyński W Abstract The study objective was to assess the prevalence of cardiovascular disease risk factors in patients treated for childhood cancer (N = 101) and to determine the involvement of clinical (cancer type and therapy) and/or genetic (FTO gene rs9939609 polymorphism) factors. Anthropometric features, laboratory findings, and standardized osteodensitometric indices (fat and lean mass) were considered. Overweight/obesity was found in 17.82% of the patients; however, central adiposity was found in as m...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
A THERAPY that could make lung cancer treatable is “one of the biggest breakthroughs in cancer in years”. It combines two drugs and “decloaks” the cancer, revealing it to the body’s immune system that in turn attacks it.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Klein S, Aung T, Haas RM, Medved F, Schiller SM, Felthaus O, Dolderer JH Abstract Soft tissue defects resulting from injuries, tumor resection, congenital anomalies or chronic wounds pose a great challenge to reconstructive surgery. The current gold standard in therapy of such defects is the tissue transplantation in terms of free or local flaps. Unfortunately, donor site morbidity remains a considerable risk of flap surgery. Therefore, tissue engineering of autologous vascularized long term stable adipose tissue constructs could enrich the therapeutic possibilities of soft tissue defects. De novo adipose ...
Source: Handchirurgie Mikrochirurgie Plastische Chirurgie - Category: Cosmetic Surgery Tags: Handchir Mikrochir Plast Chir Source Type: research
Conclusion. Evidence from the meta-analysis suggested that JPBS combined with chemotherapy has a positive effect on gastric cancer treatment. However, additional rigorously designed and large sample randomized controlled trials are required to confirm the efficacy and safety of this treatment. PMID: 29675052 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Fung C, Dinh P, Ardeshir-Rouhani-Fard S, Schaffer K, Fossa SD, Travis LB Abstract Testicular cancer has become the paradigm of adult-onset cancer survivorship, due to the young age at diagnosis and 10-year relative survival of 95%. This clinical review presents the current status of various treatment-related complications experienced by long-term testicular cancer survivors (TCS) free of disease for 5 or more years after primary treatment. Cardiovascular disease and second malignant neoplasms represent the most common potentially life-threatening late effects. Other long-term adverse outcomes include neuro...
Source: Advances in Urology - Category: Urology & Nephrology Tags: Adv Urol Source Type: research
Authors: Nayan M, Hamilton RJ Abstract Testicular cancer is the most common malignancy in young men, and the incidence is increasing in most countries worldwide. The vast majority of patients present with clinical stage I disease, and surveillance is being increasingly adopted as the preferred management strategy. At the time of diagnosis, patients on surveillance are often counselled about their risk of relapse based on risk factors present at diagnosis, but this risk estimate becomes less informative in patients that have survived a period of time without experiencing relapse. Conditional survival estimates, on t...
Source: Advances in Urology - Category: Urology & Nephrology Tags: Adv Urol Source Type: research
Inflammatory Human Umbilical Cord-Derived Mesenchymal Stem Cells Promote Stem Cell-Like Characteristics of Cancer Cells in an IL-1β-Dependent Manner. Biomed Res Int. 2018;2018:7096707 Authors: Luo X, Huang S, He N, Liu C, Chen Y, Liu Y, Mi X, Li N, Sun P, Li Z, Xiang R, Su W Abstract To ensure the safety of clinical applications of MSCs, thorough understanding of their impacts on tumor initiation and progression is essential. Here, to further explore the complex dialog between MSCs and tumor cells, umbilical cord-derived mesenchymal stem cells (UC-MSCs) were employed to be cocultured with either ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Abstract Ageing, which is associated with a progressive decline and functional deterioration in multiple organ systems, is highly heterogeneous, both inter- and intraindividually. For this, tailored-made theranostics and optimum patient stratification become fundamental, when decision-making in elderly patients is considered. In particular, when cancer incidence and cancer-related mortality and morbidity are taken into account, elderly patient care is a public health concern. In this review, we focus on oncogeriatrics and highlight current opportunities and challenges with an emphasis on the unmet need of clinical...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
In this study, we establish the procedure for preparing skin fibroblast clones whose genes were edited by the CRISPR/Cas9 technique. After isolating fibroblasts from earlobes of Japanese Black cattle, subsequent collagenase-digestion and extensive wash procedures enabled us to avoid contamination of fungi. Electroporation using NEPA21, rather than lipofection using commercially available liposome reagents, allowed us to perform more efficient transfection of plasmid constructs. Although bovine ear-derived fibroblasts were not able to proliferate in single cell cultures in Dulbecco's modified Eagle medium containing 10% fet...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Source Type: research
This study aimed to evaluate the impact of donor HTN on patient survival of SLKT recipients and to identify independent risk factors. MATERIAL AND METHODS Data from 3844 adult SLKT recipients receiving deceased donor grafts from March 2002 to December 2014 in the Scientific Registry of Transplant Recipients (SRTR) database were retrospectively analyzed. Kaplan-Meier analysis was used to compare patient and graft survival. Multivariate Cox proportional hazard models were built to identify independent risk factors associated with patient and graft survival. RESULTS SLKT patients receiving HTN donor grafts had significantly s...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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