Patients with aortic stenosis have von Willebrand factor abnormalities and increased proliferation of endothelial colony forming cells.

CONCLUSIONS: AS patients exhibited quantitative and qualitative abnormalities of VWF including significantly increased VWF antigen, activity, and propeptide levels following surgery (p<0.01). Increased high molecular weight VWF multimers were observed at all time points and in particular three to five days after surgery (mean = 14±6%) relative to before (mean = 10±4%), suggesting increased proteolysis by ADAMTS13 pre-operatively in a shear-dependent manner. ECFCs from patients with aortic stenosis were more proliferative than controls (P<0.05) and had increased retention of Ang-2 (P<0.05) suggesting epigenetic modification of the cells. Overall, there are hemostatic changes in AS patients that are present before valve replacement surgery and these persist long after surgery has occurred. These findings have implications for the current clinical management of AS patients. PMID: 31860769 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: J Thromb Haemost Source Type: research