Endogenously released GIP reduces and GLP-1 increases hepatic insulin extraction

ConclusionEndogenously released GIP correlated with reduced, and GLP-1 with increased hepatic insulin extraction. Increased peripheral insulin levels may contribute to insulin resistance and obesity. We propose that the unfavorable effects of high glycemic index Western diets are related to increased GIP-release and reduced HIC.
Source: Peptides - Category: Biochemistry Source Type: research