Cancer Cell-Derived Secretory Factors in Breast Cancer Associated Lung Metastasis; their Mechanism and its Future Prospects.

Cancer Cell-Derived Secretory Factors in Breast Cancer Associated Lung Metastasis; their Mechanism and its Future Prospects. Curr Cancer Drug Targets. 2019 Dec 20;: Authors: Urooj T, Wasim B, Mushtaq S, Shah SNN, Shah M Abstract In Breast cancer, Lung is the second most common site of metastasis after bone. Various factors are responsible for the mechanism of Lung metastasis occurring secondary to Breast cancer. Cancer cell-derived secretory factors are commonly known as 'Cancer Secretomes'. They exhibit prompt role in the mechanism of Breast cancer lung metastasis. They are also the major constituents of host-associated tumor microenvironment. Through cross-talk between cancer cells and the extracellular matrix components, cancer cell-derived extracellular matrix components (CCECs) such as hyaluronan, collagens, laminin and fibronectin causes ECM remodeling at the primary site (breast) of cancer. However at the secondary site (lung), tenascin C, periostin and lysyl oxidase, along with pro-metastatic molecules; Coco and GALNT14, by promoting ECM remodeling and lung metastatic cells colonization, contribute in the formation of pre-metastatic niche (PMN). The cancer cell-derived secretory factors by inducing cancer cell proliferation at the primary site, their invasion through the tissues and vessels and early colonization of metastatic cells in the PMN thereby, potentiates the mechanism of Lung metastasis in Breast cancer. On the basi...
Source: Current Cancer Drug Targets - Category: Cancer & Oncology Authors: Tags: Curr Cancer Drug Targets Source Type: research