Diagnosing Anal Squamous Intraepithelial Lesions With and Without p16: An Interobserver Variability Study

Conclusions
This study highlights the importance of a judicious use of p16 for diagnosis. When there is no need for p16 by the Lower Anogenital Squamous Terminology guidelines, interobserver agreement was substantial to almost perfect with a 2-tiered diagnosis. However, when its use is indicated but it is not performed or reviewed, the agreement is much lower even with a 2-tiered diagnosis. Rational use of p16 will ensure diagnostic accuracy and the best possible patient care.

Source: Journal of Lower Genital Tract Disease - December 21, 2019 Category: OBGYN Tags: Anal Disease Source Type: research