Opportunistic invasive fungal disease in patients with type  2 diabetes mellitus from Southern China: Clinical features and associated factors

We investigated the characteristics and associated factors of invasive fungal disease in patients with type  2 diabetes mellitus from Southern China for the first time. We found thatCandida albicans,Cryptococcus neoformans andAspergillus fumigatus were the leading agents. Prolonged hyperglycemia results in unfavorable outcomes. Correction of anemia and hypoalbuminemia might improve prognosis. AbstractAims/IntroductionA retrospective study was carried out to investigate the clinical characteristics and associated factors for invasive fungal disease in patients with type  2 diabetes mellitus.Materials and MethodsDemographic and clinical data were recorded. Associated factors were analyzed by logistic regression analysis.ResultsInvasive fungal disease was diagnosed in 120 patients with type  2 diabetes mellitus (prevalence, 0.4%). Yeast infection (56/120, 46.7%), including candidiasis (31/56, 55.4%) and cryptococcosis (25/56, 44.6%), was the most common. The urinary tract was mainly involved in candidiasis (12/31, 38.7%). More than half of the cryptococcosis (16/25, 64.0%) presented a s pneumonia. Mold infection accounted for 40.8% of the cases, and predominantly involved the lung (34/49, 69.4%). A total of 15 (12.5%) patients had mixed fungal infection.Candida albicans (24/111, 21.6%),Cryptococcus neoformans (19/111, 17.1%) andAspergillus fumigatus (14/111, 12.6%) were the leading agents. Co ‐infection occurred in 58 (48.3%) patients, mainly presenting as pneum...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Original Article Source Type: research

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CONCLUSIONS: The average patient is middle aged (often male) with a history of subacute back pain, sometimes presenting fever and/or neurological damage on diagnosis. Acute phase reactants are frequently raised. Diabetes mellitus, endocarditis and immunosuppressed patients may have the worst chance of a good outcome, therefore these patients should be more carefully managed (always try to obtain an imaging-guided biopsy, correct antibiotic treatment, and a functional and clinical follow-up). PMID: 32446680 [PubMed - as supplied by publisher]
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This study, for instance, attributes a patient’s waitlist/transplant outcome to the very last dialysis facility the patient was associated with.  In epidemiology speak, this means the causal inference authors are trying to draw between for-profit status and good transplant outcomes is subject to time-varying confounding. As an example, if one is seeking an association between testosterone levels and risk of a heart attack, using the last testosterone level available would be a poor way of doing this study because testosterone levels are known to vary over time. The same applies to dialysis facilities. Patie...
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AbstractObjectivesA retrospective study was performed to investigate the clinical characteristics and associated factors for invasive fungal disease (IFD) in patients with type 2 diabetes mellitus (T2DM).MethodsDemographic and clinical data were recorded. Associated factors were analyzed by logistic regression analysis.ResultsIFD was diagnosed in 120 patients with T2DM (prevalence, 0.4%). Yeast infection (56/120, 46.7%), including candidiasis (31/56, 55.4%) and cryptococcosis (25/56, 44.6%) was the most common. Urinary tract was mainly involved in candidiasis (12/31, 38.7%). More than half of the cryptococcosis (16/25, 64....
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: ORIGINAL ARTICLE Source Type: research
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