Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities

AbstractObjectivesPaeoniflorin, a representative pinane monoterpene glycoside in plants ofPaeoniaceae family, possesses promising anticancer activities on diverse tumours. This paper summarized the advance of Paeoniflorin on cancersin vivo andin vitro, discussed the related molecular mechanisms, as well as suggested some perspectives of the future investigations.Key findingsAnticancer activities of paeoniflorin have been comprehensively investigated, including liver cancer, gastric cancer, breast cancer, lung cancer, pancreatic cancer, colorectal cancer, glioma, bladder cancer and leukaemia. Furthermore, the potential molecular mechanisms corresponding to the antitumour effects of Paeoniflorin might be related to the following aspects: inhibition of tumour cell proliferation and neovascularization, induction apoptosis, and inhibition of tumour invasion and metastasis.SummaryPaeoniflorin has wide spectrum antitumour activities; however, in vivo and clinical investigations on antitumour effect of Paeoniflorin are lacking which should be focused on further studies. Our present review on antitumour effects of Paeoniflorin would be beneficial for the further molecular mechanisms study, candidate antitumour drug development and clinical research of Paeoniflorin in the future.
Source: Journal of Pharmacy and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research

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Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
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Source: Breast Disease - Category: Cancer & Oncology Tags: Breast Dis Source Type: research
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Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
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Source: Pathology Research and Practice - Category: Pathology Source Type: research
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
This study was supported by the Shanghai Sailing Program [grant number 17YF1425200, 2017]; Chinese National Natural Science Funding [grant number 81702249, 2017]; Science and Technology Commission of Shanghai Municipality [grant number 17511103403, 2017]; The funder has no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We acknowledge the ex...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
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