Genomic and phenotypic characterization of a broad panel of patient derived xenografts reflects the diversity of glioblastoma.

CONCLUSIONS: Our PDX panel captures the molecular heterogeneity of glioblastoma and recapitulates many salient genetic and phenotypic features. All models and genomic data are openly available to investigators.
PMID: 31852831 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - December 17, 2019 Category: Cancer & Oncology Authors: Vaubel RA, Tian S, Remonde D, Schroeder MA, Mladek AC, Kitange GJ, Caron A, Kollmeyer TM, Grove R, Peng S, Carlson BL, Ma DJ, Sarkar G, Evers L, Decker PA, Yan H, Dhruv HD, Berens ME, Wang Q, Marin BM, Klee EW, Califano A, LaChance DH, Eckel-Passow JE, Ve Tags: Clin Cancer Res Source Type: research