The dissolution behavior and apparent thermodynamic analysis of propacetamol hydrochloride in pure and mixed solvents

Publication date: Available online 19 December 2019Source: The Journal of Chemical ThermodynamicsAuthor(s): Yüfang Wu, Yuancong Wu, Xiaolu ZhangAbstractIn order to study the solubility of the formed solute in the reaction solvent, the solubility of propacetamol hydrochloride (PRO) in pure and mixed solvents was experimentally determined at T = 273.15-313.15K. In all selected pure solvents, the solubility data form high to low was followed by the sequence: methanol> ethanol> acetone> n-propanol> isopropanol> acetonitrile. In mixture of (acetone + ethanol), the solubility decreased monotonically with the increasing mass fraction of acetone in mixed solvents at a certain temperature. The properties of solvents and the interaction between solvents and solutes were analyzed. All RAD values in the modified Apelblat equation are less than those in λh equation. Therefore, modified Apelblat is more suitable for correlating the solubility data of PRO in selected pure solvents. In addition, satisfactory correlation results in (acetone + ethanol) were obtained by Jouyban-Acree model. The values of ΔHsoloand ΔSsolo are all positive in this experiment, which indicates the dissolution process is not only endothermic but also entropy-driving. Moreover, the values of %ξH are greater than those of %ξTS, which indicates the enthalpy is the main contributor to the change of standard Gibbs energy during the dissolution process of PRO.Graphical abstract

Source: The Journal of Chemical Thermodynamics - December 20, 2019 Category: Chemistry Source Type: research