Prenatal infection with Mycoplasma pulmonis in rats exaggerates the angiotensin II pressor response in adult offspring.

In this study, the impact of prenatal infection (PNI), using a naturally occurring rodent pathogen, Mycoplasma pulmonis (MP), on adult body weight and cardiovascular function was evaluated. Pregnant Sprague Dawley rats were infected with MP on gestational day 14 and gave birth naturally. Adult PNI offspring of weighed more than controls, but resting mean arterial pressure (MAP) was unchanged. Subcutaneous injection of angiotensin II (Ang II; 10 μg/kg) elicited a rise in MAP that was greater in both male and female PNI offspring compared to controls (P
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

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AbstractObjectiveTo investigate the possible role of serum norepinephrine (NE), leptin and 5 ‐hydroxytryptamine (5‐HT) and their correlations with sympathetic skin response located in the penis (PSSR) in primary premature ejaculation (PPE).MethodsWe compared the serum level of NE, leptin and 5 ‐HT, Intravaginal ejaculatory latency time(IELT) and The Premature Ejaculation Diagnostic Tool (PEDT) scores between 57 PPE patients and 42 healthy control men as controls, who were recruited between September 2016 and January 2019. Additionally, the amplitude and latency of PSSR were measured and compared between the two group...
Source: Andrology - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionsCaffeine was a marker for increased intake of calories and decreased intake of key nutrients. When discussing dietary intake in early childhood, practitioners should screen for nutrient deficiency in young children and recommend limiting the intake of caffeinated foods and beverages.
Source: Academic Pediatrics - Category: Pediatrics Source Type: research
In conclusion, in the absence of obesity, visceral adipose tissue possesses a pronounced anti-inflammatory phenotype during aging which is further enhanced by exercise. Methods of Inducing Cellular Damage are Rarely Relevant to Aging, and the Details Matter https://www.fightaging.org/archives/2019/08/methods-of-inducing-cellular-damage-are-rarely-relevant-to-aging-and-the-details-matter/ One of the major challenges in aging research is determining whether or not models of cellular or organismal damage and its consequences are in any way relevant to the natural processes of aging. One can hit a brick with...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Katherine Samaras1,2,3*, Henrik Tevaerai4, Michel Goldman5, Johannes le Coutre6,7 and Jeff M. P. Holly8 1Department of Endocrinology, St Vincent's Hospital, Darlinghurst, NSW, Australia 2Diabetes and Metabolism, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia 3St Vincent's Hospital, St Vincent's Clinical School, Darlinghurst, NSW, Australia 4Bern University Hospital, Bern, Switzerland 5Institute for Interdisciplinary Innovation in Healthcare, Universite Libre de Bruxelles, Bruxelles, Belgium 6Department of Medicine, Imperial College London, London, United Kingdom 7Nes...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 18 June 2018Source: Molecular MetabolismAuthor(s): Jessica H. Beeson, Heather L. Blackmore, Sarah K. Carr, Laura Dearden, Daniella E. Duque-Guimarães, Laura C. Kusinski, Lucas C. Pantaleão, Adele G. Pinnock, Catherine E. Aiken, Dino A. Giussani, Denise S. Fernandez-Twinn, Susan E. OzanneAbstractObjectiveObesity during pregnancy is associated with an elevated risk of cardiovascular disease in the offspring. With increased numbers of women entering pregnancy overweight or obese, there is a requirement for targeted interventions to reduce disease risk in future generations. Usi...
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
Conclusions Exercise in obese pregnancy was beneficial to offspring cardiac function and structure but did not influence hypertension suggesting they are programmed by separate mechanistic pathways. These data suggest combination interventions in obese pregnancies will be required to improve all aspects of the cardiovascular health of the next generation. Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
We present updates on the complex interactions of these two systems with dietary salt intake in relation to obesity, insulin resistance, inflammation, and oxidative stress. We review how insults during pregnancy such as matern al and paternal malnutrition, glucocorticoid exposure, infection, placental insufficiency, and treatments during the neonatal period have long-lasting effects in the regulation of renal function and BP. Moreover, these effects have sex differences. There is a need for early diagnosis, frequent monit oring, and timely management due to increasing evidence of premature target organ damage. Large contro...
Source: Current Hypertension Reports - Category: Primary Care Source Type: research
Although it is known that obesity is a risk factor for preeclampsia (PE), the mechanisms are not clear. Placental ischemia stimulates the release of the antiangiogenic factor sFlt-1 into the maternal circulation eliciting vascular dysfunction and hypertension. Therefore, we tested the hypothesis that placental ischemia (reduced uterine perfusion pressure, RUPP)-induced hypertension and sFlt-1 levels are exaggerated in obese rats. MC4R-deficient obese rats (MC4R+/-) and wild-type Wistar Hannover controls (MC4R+/+) were maintained on NIH31 standard chow; mated at 17 weeks old; RUPP surgeries performed at gestational day (GD)...
Source: Hypertension - Category: Cardiology Authors: Tags: Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception Source Type: research
The prevalence of obesity in women among child baring age is increasing and this has been parallel to the increase in obesity in general population around the world. We investigated the trans-generational ‘programming’ of leptin signalling in the central nervous system (CNS) to increase blood pressure (BP), heart rate (HR) and renal sympathetic nerve activity (RSNA) following a high fat diet (HFD)feeding in mothers. Female New Zealand White rabbits were fed a high fat (13%) diet (mHFD) or a control diet (mCD) prior mating and during pregnancy.
Source: Autonomic Neuroscience: Basic and Clinical - Category: Neuroscience Authors: Tags: P9.6 Source Type: research
Authors: Alexander BT, Dasinger JH, Intapad S Abstract Low birth weight serves as a crude proxy for impaired growth during fetal life and indicates a failure for the fetus to achieve its full growth potential. Low birth weight can occur in response to numerous etiologies that include complications during pregnancy, poor prenatal care, parental smoking, maternal alcohol consumption, or stress. Numerous epidemiological and experimental studies demonstrate that birth weight is inversely associated with blood pressure and coronary heart disease. Sex and age impact the developmental programming of hypertension. In addit...
Source: Comprehensive Physiology - Category: Physiology Tags: Compr Physiol Source Type: research
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