Atorvastatin protects cardiomyocyte from doxorubicin toxicity by modulating survivin expression through FOXO1 inhibition

Survivin has an anti-apoptotic effect against anthracycline-induced cardiotoxicity. Clinically, statin use is associated with a lower risk for heart failure in breast cancer patients with anthracycline chemotherapy. So, the purpose of our study was to investigate whether survivin mediates the protective effect of statin against anthracycline-induced cardiotoxicity.

Source: Journal of Molecular and Cellular Cardiology - December 18, 2019 Category: Cytology Authors: Jaewon Oh, Beom Seob Lee, Gibbeum Lim, Heejung Lim, Chan Joo Lee, Sungha Park, Sang-Hak Lee, Ji Hyung Chung, Seok-Min Kang Source Type: research