Population-based risk factors for community-onset bloodstream infections

AbstractAlthough a number of comorbidities have been associated with development of bloodstream infection, actual risk factors have not been well defined and quantified in nonselected populations. We sought to quantify population-based risk factors for development of community-onset bloodstream infection (COBSI). Surveillance was conducted among all residents of the Western Interior of British Columbia, Canada, during 2011 –2018. Risks were expressed as incidence rate ratios (IRR) with 95% confidence intervals (CI). The annual incidence was 147.1 per 100,000 and older individuals, and males were at overall higher risk. The median Charlson score was 2 (IQR, 0–3), and this was higher among those with healthcare-asso ciated (2; IQR, 1–4) as compared to community-associated (1; IQR, 0–2;P< 0.0001) COBSI. Risk factors for development of COBSI included (IRR; 95% CI): HIV infection (8.89; 5.17 –14.27), cancer (6.80; 6.13–7.54), congestive heart failure (4.68; 4.00–5.46), dementia (3.31; 2.82–3.87), diabetes mellitus (3.10; 2.80–3.42), cerebrovascular accident (2.79; 2.34–3.31), renal dysfunction (2.75; 2.33–3.22), chronic lung disease (2.03; 1.79–2.28), peripheral vascular disease (1.68; 1.39–2.01), and rheumatic disease (1.44; 1.14–1.79). Patients with multiple comorbid illnesses were older, more likely to be male, and have healthcare-associated BSI, higher rates of antimicrobial resistance, and different clinical foci of infection. A number of demogr...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research