GRADE notes: Extremely Serious, GRADE ’s Terminology for Rating Down by 3-Levels

The GRADE system for assessing certainty in a body of evidence currently uses two-levels, serious and very serious, for downgrading on a single domain. In the context of newer risk of bias instruments, such as ROBINS-I, evidence generated by non-randomised studies may justify rating down by more than 2 levels on a single domain. Given the importance users of GRADE assign to terminology, our objective was to assess what term GRADE stakeholders would prefer for rating down certainty by 3 levels.

Source: Journal of Clinical Epidemiology - December 18, 2019 Category: Epidemiology Authors: Thomas Piggott, Rebecca L. Morgan, Carlos A. Cuello-Garcia, Nancy Santesso, Reem A. Mustafa, Joerg J. Meerpohl, Holger J. Sch ünemann, GRADE Working Group Tags: Original Article Source Type: research