Crimean-Congo Haemorrhagic Fever: Annual Epidemiological Report for 2018; Surveillance Report
Source: European Union, European Centre for Disease Prevention and Control (ECDC). Published: 12/2019. This three-page report on cases of Crimean-Congo hemorrhagic fever is based on data for 2018 retrieved from The European Surveillance System (TESSy) on September 10, 2019. For 2018, European Union/European Economic Area countries reported eight cases of Crimean-Congo hemorrhagic fever. Bulgaria reported six locally-acquired confirmed cases, Greece one travel-related confirmed case, and Spain one locally-acquired probable case. (PDF)
Crimean-Congo hemorrhagic fever is the most geographically widespread tick-borne virus, with infection resulting in mortality in up to 30% of cases. Clinical diagnosis alone is difficult due to the nonspecific nature of symptoms; therefore, laboratory diagnostics should be utilized for patients with residence in or travel to regions of endemicity in whom the disease is suspected. This minireview provides an overview of laboratory tests available for Crimean-Congo hemorrhagic fever (CCHF) and their utility in diagnosis with a focus on diagnosing CCHF in humans.
AbstractCrimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease with a mortality rate of up to 50% in humans. To avoid safety concerns associated with the use of live virus in virus neutralization assays and to detect human serum neutralizing antibodies, we prepared lentiviral particles containing the CCHF glycoprotein (lenti-CCHFV-GP). Incorporation of the GP into the lentiviral particle was confirmed by electron microscopy and Western blotting. Lenti-CCHFV-GP was found to be able to infect a wide range of cell lines, including BHK-21, HeLa, HepG2, and AsPC-1 cells. In addition, lenti-CCHFV-GP was successfully used...
B. Boushab et al.
A. Zohaib et al.
Vector-Borne and Zoonotic Diseases, Ahead of Print.
ConclusionsThe highest seroprevalence of CCHF is found in central and eastern European countries. Southern and western Europe countries, such as Greece and Spain, have low levels of endemicity, but the spread of the infection, which is associated with climate change, is a possibility that we should keep in mind. Further studies, especially larger seroprevalence studies in humans and animals, are needed to establish the current status of the CCHF epidemiology and to generate standardized guidelines for action in the region.
Abstract We conducted a cross-sectional survey of Crimean-Congo hemorrhagic fever virus (CCHFV) in dromedary camels and attached ticks at 3 locations in the United Arab Emirates. Results revealed a high prevalence of CCHFV-reactive antibodies in camels and viral RNA in ticks and camel serum, suggesting the virus is endemic in this country. PMID: 32097111 [PubMed - as supplied by publisher]
D. Oluwayelu et al.
J. V. Camp et al.
Publication date: Available online 5 February 2020Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Hassan NasirianAbstractCrimean-Congo hemorrhagic fever (CCHF) is the most popular tick-borne disease causing by Crimean-Congo hemorrhagic fever virus (CCHFV). There are several valuable reviews considering some fields of the CCHF aspects. While there is no a systematic review about means and trends of CCHF cases and fatality rate, means and trends of CCHF cases and fatality rates of human occupations involved in CCHF. Therefore, this meta-analysis review performed to highlight and provide a globa...