G öttingen minipig is not a suitable animal model for in vivo testing of tissue-engineered corneal endothelial cell-carrier sheets and for endothelial keratoplasty.

CONCLUSIONS: In conclusion, the minipig is not suitable for corneal transplantation studies in vivo because of intraoperative challenges and development of retrocorneal membrane postoperatively. For in vivo testing of the surgical handling and the therapeutic potential of tissue-engineered endothelial cell-carrier constructs other animal models are required.
PMID: 31851850 [PubMed - as supplied by publisher]

Source: Current Eye Research - December 17, 2019 Category: Opthalmology Authors: Telinius N, Spinozzi D, Rasic D, Dapena I, Baandrup U, Miron A, Oellerich S, Hjortdal J Tags: Curr Eye Res Source Type: research