Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis
Epidemiological studies demonstrate an association between asthma and mental health disorders, although little is known about the shared genetics and causality of this association. Thus, we aimed to investigate shared genetics and the causal link between asthma and mental health disorders. We conducted a large-scale genome-wide cross-trait association study to investigate genetic overlap between asthma from the UK Biobank and eight mental health disorders from the Psychiatric Genomics Consortium: attention deficit hyperactivity disorder (ADHD), anxiety disorder (ANX), autism spectrum disorder, bipolar disorder, eating disorder, major depressive disorder (MDD), post-traumatic stress disorder and schizophrenia (sample size 9537–394 283). In the single-trait genome-wide association analysis, we replicated 130 previously reported loci and discovered 31 novel independent loci that are associated with asthma. We identified that ADHD, ANX and MDD have a strong genetic correlation with asthma at the genome-wide level. Cross-trait meta-analysis identified seven loci jointly associated with asthma and ADHD, one locus with asthma and ANX, and 10 loci with asthma and MDD. Functional analysis revealed that the identified variants regulated gene expression in major tissues belonging to the exocrine/endocrine, digestive, respiratory and haemic/immune systems. Mendelian randomisation analyses suggested that ADHD and MDD (including 6.7% sample overlap with asthma) might increase the ris...
During National Suicide Prevention Awareness Month, NIMH hosted a livestream event on suicide prevention during the pandemic, focusing on unemployment, youth, and other population subgroups who may be experiencing elevated risk.
This study aims to explore the overlap between symptoms of depression, anxiety, irritability and aggressiveness in autism spectrum disorder (ASD), to measure specific and idiosyncratic emotional responses. A total of 42 high functioning adolescents and adults, between 12 and 39 years old, meeting the diagnostic and statistical manual of mental disorders – 5 criteria for ASD were selected from the InFoR Autism cohort. Data were analyzed in an exploratory way using Hill and Smith and K-medoids cluster analysis. The authors found an aggregation of anxiety, depression, aggressive behaviors and irritability. ...
Methamphetamine use in adults aged 18 to 64 years increased 43% between 2015 and 2019, astudy in JAMA Psychiatry has found. The study also found that overdose deaths involving psychostimulants other than cocaine, mostly methamphetamine, increased 180% during the same period.Beth Han, M.D., Ph.D., M.P.H., of the National Institute on Drug Abuse (NIDA) and colleagues examined data from 195,711 people who responded to the annual National Survey on Drug Use and Health (NSDUH) between 2015 and 2019. The NSDUH, published by the Substance Abuse and Mental Health Services Administration, is a comprehensive survey of approximately ...
Condition: Postpartum Depression Interventions: Behavioral: Motherly app; Behavioral: COMVC app Sponsor: University of Sao Paulo Not yet recruiting
Condition: Asthma Intervention: Other: Pharmaceutical Teleconsultation Sponsors: Federal University of Rio Grande do Sul; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Not yet recruiting
Conditions: Depression; Perinatal Depression; Anxiety; Pregnancy Related Interventions: Behavioral: Online therapy with coaching; Behavioral: Clinical care Sponsor: University of California, Los Angeles Recruiting
Conditions: Psychiatric or Mood Diseases or Conditions; Neuropsychiatric Syndrome; Psychosis; Autism; Severe Mental Disorder Interventions: Other: Everyday Life Rehabilitation (ELR); Other: Treatment as usual (TAU) Sponsors: Umeå University; Swedish Council for Working Life and Social Research Recruiting
Condition: Quality of Life Intervention: Sponsor: Assiut University Not yet recruiting
The ’90s-era supermodel said side effects from a fat-freezing procedure caused her to become depressed and turned her into a recluse after “not looking like myself any longer.”
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