What Does Chronic Myeloid Leukaemia Tell Us About Other Leukaemias?

AbstractPurpose of ReviewDetermine if therapy of chronic myeloid leukaemia (CML) is a model for treating other cancers.Recent FindingsCML has a relatively homogeneous phenotype and genotype and is caused by one mutation,BCRABL1, in every instance. In contrast, most other leukaemias, haematologic cancers and solid cancer have more heterogeneous phenotypes and extraordinarily greater genotypic diversity and mutational complexity.SummaryLesions learned from treating CML have little applicability to other leukaemias, haematologic cancers or solid cancer.
Source: Current Hematologic Malignancy Reports - Category: Hematology Source Type: research