Diabetes mellitus alters electrophysiological properties in neurons of superior cervical ganglion of rats.

In conclusion, we have demonstrated that DM affects several parameters of SCG physiology in a manner likely to have pathophysiological relevance. PMID: 31843626 [PubMed - as supplied by publisher]
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research

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Publication date: Available online 19 February 2020Source: Journal of Molecular StructureAuthor(s): S. Pangajavalli, R. Ranjithkumar, S. RamaswamyAbstractIn the present study, a novel 6b', 7', 8', 9'-Tetrahydro-2H,6'H-Spiro [acenaphthylene-1,11'-chromeno [3,4-a] pyrrolizine]-2,6'(6a'H,11a'H)- dione (ACPD) single crystal was grown by the slow evaporation method. The single crystal X-ray diffraction analysis and density functional theory (DFT) calculations were carried out for the ACPD molecule. The ACPD crystallizes in the orthorhombic space group Pbca with a = 18.3519 (14) Å, b = 11.3883 (9) Å, c = 18.3545 (14)...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 19 February 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Azrul Abdul Kadir, Kieran Clarke, Rhys D. EvansAbstractThe ketone bodies, d-β-hydroxybutyrate and acetoacetate, are soluble 4-carbon compounds derived principally from fatty acids, that can be metabolised by many oxidative tissues, including heart, in carbohydrate-depleted conditions as glucose-sparing energy substrates. They also have important signalling functions, acting through G-protein coupled receptors and histone deacetylases to regulate metabolism and gene expression including ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Publication date: Available online 19 February 2020Source: Redox BiologyAuthor(s): Cláudia Figueiredo-Pereira, Daniela Dias-Pedroso, Nuno L. Soares, Helena L.A. VieiraAbstractCarbon monoxide (CO) is a gasotransmitter endogenously produced by the activity of heme oxygenase, which is a stress-response enzyme. Endogenous CO or low concentrations of exogenous CO have been described to present several cytoprotective functions: anti-apoptosis, anti-inflammatory, vasomodulation, maintenance of homeostasis, stimulation of preconditioning and modulation of cell differentiation. The present review revises and discuss how CO r...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: Available online 19 February 2020Source: Life SciencesAuthor(s): Panpan Liu, Wu Zhu, Chao Chen, Bei Yan, Lei Zhu, Xiang Chen, Cong PengAbstractLysophosphatidylcholine (LPC) is the main component of oxidatively damaged low-density lipoprotein (oxLDL). LPC originates from the cleavage of phosphatidylcholine by phospholipase A2 (PLA2). LPC plays a biological role by binding to G protein-coupled receptors and Toll-like receptors. LPC can induce the migration of lymphocytes and macrophages, increase the production of pro-inflammatory cytokines, induce oxidative stress, and promote apoptosis, which can aggregat...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 19 February 2020Source: Polymer Degradation and StabilityAuthor(s): Marziyeh Ranjbar Mohammadi, Saeid Kargozar, S.H. Bahrami, Shahram RabbaniAbstractIn this research, the scaffolds from gum tragacanth (GT), poly (Ɛ-caprolactone) (PCL) and poly (vinyl alcohol) (PVA), were fabricated by electrospinning method for use in the healing of diabetic ulcers. At first, three different compositions from PCL-GT-PVA with blend ratios of (2:1:0.5), (2:1:0.8) and (2:1:1.5) were fabricated and the formulation 2:1:0.8 was selected as proper one. Then, the effect of changing GT concentration on the morpho...
Source: Polymer Degradation and Stability - Category: Chemistry Source Type: research
Conclusion: Unsupervised machine-learning algorithms applied to a wide range of biomarkers identified 2 HFpEF clusters with different CV phenotypes and outcomes. The identified pathways may provide a basis for future research.Clinical significanceMore insight is obtained in the mechanisms related to poor outcome in HFpEF patients since it was demonstrated that biomarkers associated with the high-risk cluster were related to the immune system, signal transduction cascades, cell interactions and metabolismBiomarkers (and pathways) identified in this study may help select high-risk HFpEF patients which could be helpful for th...
Source: Biomarkers - Category: Research Tags: Biomarkers Source Type: research
Publication date: Available online 24 January 2020Source: Journal of Genetics and GenomicsAuthor(s): Qianru Huang, Xu Liu, Yujia Zhang, Jingyao Huang, Dan Li, Bin LiAbstractRegulatory T (Treg) cells, a subtype of immunosuppressive CD4+ T cells, are vital for maintaining immune homeostasis in healthy people. Forkhead box protein P3 (FOXP3), a member of the forkhead–winged-helix family, is the pivotal transcriptional factor of Treg cells. The expression, post-translational modifications, and protein complex of FOXP3 present a great impact on the functional stability and immune plasticity of Treg cells in vivo. In ...
Source: Journal of Genetics and Genomics - Category: Genetics & Stem Cells Source Type: research
Treatment with novel HYBENX® root canal cleanser suggests biofilms blocked healing of human wounds: case series. J Biol Regul Homeost Agents. 2020 Jan-Feb;34(1 Suppl. 1):1-11 Authors: DENTAL SUPPLEMENT, Gitterle M Abstract Pathogenic biofilms are considered a potential major obstacle to healing chronic wounds. The six-month evaluation period in this study assessed the effect of a single treatment of the HYBENX® (HYB) Root Canal Cleanser on chronic wounds, especially its ease of use, safety, potential for shortening duration of Inflammatory Phase, and promotion of granulation. HYB gel was applie...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
CONCLUSION: Collectively, these findings suggest that the increased ventricular arrhythmia susceptibility of type 2 diabetic mouse hearts is due to dysregulation of the sympathetic ventricular control. PMID: 31625779 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
Publication date: Available online 6 September 2018Source: Neurochemistry InternationalAuthor(s): Xuan Sheng, Yu Dan, Bo Dai, Jingjing Guo, Huihong Ji, Xinge Zhang, Zhi Xie, Siqi Song, Qiwen Pan, Jiayue Wang, Shangdong Liang, Guilin LiAbstractDiabetic cardiac autonomic neuropathy (DCAN) is a common and serious complication of diabetes mellitus (DM), is manifested by nerve fiber injury in the sympathetic and parasympathetic nerve of the autonomic nervous system, and causes hypertension, cardiac arrhythmias, silent myocardial infarction, and sudden death. Our previous study observed that P2X3 receptor in superior cervical ga...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
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