Manage congenital hyperinsulinism with pharmacotherapy and nutritional therapy based on its form, severity and response

AbstractCongenital hyperinsulinism (CHI) is rare and causes a particularly damaging form of hypoglycaemia that deprives the brain of all critical fuels (i.e. glucose, ketones and lactate). Prompt recognition and treatment are required to avoid brain damage, with some patients needing pancreatectomy. Treatment of acute hypoglycaemia usually involves dextrose or glucagon, and chronic treatment usually involves nutritional therapy (food and supplemental enteral glucose), alongside a stepwise and combination approach with various pharmacological agents (diazoxide, somatostatin analogues and glucagon, rarely nifedipine and, as a last resort, sirolimus).
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research