Brexpiprazole as a New Serotonin –Dopamine Receptor Modulator: Considering the Clinical Relevance for Metabolic Parameters and Prolactin Levels

by Masaru Nakamura, MD, PhD, and Takahiko Nagamine, MD, PhD Dr. Nakamura is with the Department of Psychiatric Internal Medicine, Kosekai-Kusatsu Hospital in Hiroshima, Japan. Dr. Nagamine is with the Department of Psychiatric Internal Medicine, Sunlight Brain Research Center in Yamaguchi, Japan. Funding: No funding was provided for this study. Disclosures: The authors have no […] The post Brexpiprazole as a New Serotonin–Dopamine Receptor Modulator: Considering the Clinical Relevance for Metabolic Parameters and Prolactin Levels appeared first on Innovations in Clinical Neuroscience.
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Drug Development Original Research Schizophrenia antipsychotics aripiprazole brexpiprazole metabolism olanzapine paliperidone Prolactin Source Type: research

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Abstract OBJECTIVE: To measure and correlate the degree of psychological well-being, quality of life, and dispositional hope in family caregivers of schizophrenic people. METHODS: Descriptive cross-sectional study conducted with 117 relatives of schizophrenic people. We applied a questionnaire of sociodemographic variables was applied, and the instruments World Health Organization 5-Item Well-Being (WHO-5), World Health Organization Quality of Life Abbreviated (WHOQOL-Bref), and Dispositional Hope Scale. We used The Kruskal Wallis, Jonckheere-Terpstra, and Spearman correlation tests at the level α
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
The successful integration of eye gaze direction and emotion cues from faces is important not only for co-ordinated interactions, but also for the detection of social signals alerting us to threat posed by a conspecific, or elsewhere in our immediate envir...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
The human insular cortex is a heterogeneous brain structure which plays an integrative role in guiding behavior. The cytoarchitectonic organization of the human insula has been investigated over the last century using postmortem brains but there has been little progress in noninvasivein vivo mapping of its microstructure and large-scale functional circuitry. Quantitative modeling of multi-shell diffusion MRI data from 413 participants revealed that human insula microstructure differs significantly across subdivisions that serve distinct cognitive and affective functions. Insular microstructural organization was mirrored in...
Source: eLife - Category: Biomedical Science Tags: Neuroscience Source Type: research
ConclusionsCareful screening and evaluation to validate diagnoses is important as the presence of certain psychiatric morbidity is common among adolescents with schizophrenia during the prodromal period. Developing acceptable and accessible interventions that will reduce psychiatric hospitalization and residential treatment care and improve care connection for schizophrenia treatment is important to mitigate complexity in treatment for adolescents and reduce cost burden for families and the society. Integrating health claims data in the development of schizophrenia risk conversion models can be useful in effectively predic...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Anhedonia, the loss or decline of the ability to enjoy pleasure, is an important clinical characteristic of schizophrenia. Schizotypal traits refer to the appearance of subclinical symptoms of schizophrenia across normal people. Still, few studies have investigated chemosensory anhedonia in schizophrenia patients and schizotypy individuals. Seventy-one schizophrenia patients (SCZ), 162 schizotypy individuals (SCT) as selected by the Schizotypal Personality Questionnaire (SPQ), and 182 healthy controls (HC) participated in our study. We used the Positive and Negative Syndrome Scale (PANSS) to measure the clinical symptoms o...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
ConclusionsIn the current study, we demonstrated an apparent sparing of ASSR-related PAC across phases of the illness, in contrast with impaired cortical gamma oscillation amplitudes. The distinction between our PAC and evoked ASSR findings supports the notion of separate but interacting circuits for the generation and maintenance of sensory gamma oscillations. The apparent sparing of PAC in both early and chronic schizophrenia patients could imply that the neuropathology of schizophrenia differentially affects these mechanisms across different stages of the disease. Future studies should investigate the distinction betwee...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
ConclusionAOM was associated with longer treatment persistence than OA in the antipsychotic treatment of patients with schizophrenia in real-world clinical settings in Japan, suggesting that the use of AOM may contribute to longer antipsychotic treatment.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Conditions:   Schizophrenia;   Schizoaffective Disorder Interventions:   Drug: AMPH;   Drug: SHAM Sponsor:   University of California, San Diego Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Schizophrenia;   Schizo Affective Disorder Interventions:   Behavioral: Emotional working memory training;   Behavioral: Placebo working memory training Sponsor:   University of Georgia Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The hidden links between mental disorders (Nature): In 2018, psychiatrist Oleguer Plana-Ripoll was wrestling with a puzzling fact about mental disorders. He knew that many individuals have multiple conditions — anxiety and depression, say, or schizophrenia and bipolar disorder. He wanted to know how common it was to have more than one diagnosis, so he got his hands on a database containing the medical details of around 5.9 million Danish citizens. He was taken aback by what he found. Every single mental disorder predisposed the patient to every other mental disorder — no matter how distinct the symptoms. &ldquo...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology anxiety biological bipolar-disorder depression Genetics JAMA Psychiatry mental illness mental-disorders National-Institute-of-Mental-Health neuroanatomy psychopathology Resear Source Type: blogs
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