An outbreak of candidemia due to Candida parapsilosis in an adult intensive care unit.

An outbreak of candidemia due to Candida parapsilosis in an adult intensive care unit. Infez Med. 2019 Dec 01;27(4):403-409 Authors: Haciseyitoğlu D, Çağ Y Abstract Candida spp. is one of the most common causes of nosocomial bloodstream infections, and Candida parapsilosis is an emerging pathogen that is associated with nosocomial outbreaks. We aimed to characterize an outbreak of candidemia due to C. parapsilosis in our hospital's adult intensive care unit to investigate the clonal relationship of isolates. This is a retrospective study designed to investigate an outbreak of C. parapsilosis bloodstream infections (BSIs) which developed during an 11-week period from July to October 2012. Thirteen outbreak isolates and five isolates from the previous five sporadic cases were included in the study. Identification and antifungal susceptibilities of the isolates were determined by using MALDI-TOF MS (VITEK MS, bioMérieux, France) and by Etest (bioMérieux, France) on RPMI 1640-2% glucose agar (bioMérieux, France) at the Clinical Microbiology Laboratory. Clonal relationships were investigated by repetitive sequence-based PCR (rep-PCR) (DiversiLab, bioMérieux, Marcy L'Étoile, France). The mean age of the cases, seven of which were female, was 61 years. The mean Candida score was 3, the mean length of stay in the intensive care unit (ICU) before infection developed was 33 days. A microbiological cure was obtained in nine (69.2%) pati...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research