H2S alleviates renal injury and fibrosis in response to unilateral ureteral obstruction by regulating macrophage infiltration via inhibition of NLRP3 signaling.

In conclusion, the therapeutic effects of H2S on UUO-induced renal injury and fibrosis are at least in part by inhibition of M1 and M2 macrophage infiltration. H2S suppresses NLRP3 activation and subsequently inactivates NF-κB and IL4/STAT6 signaling, which may contribute to the anti-inflammatory and anti-fibrotic effects of H2S.
PMID: 31846625 [PubMed - as supplied by publisher]

Source: Experimental Cell Research - December 13, 2019 Category: Cytology Authors: Zhou Y, Zhu X, Wang X, Peng Y, Du J, Yin H, Yang H, Ni X, Zhang W Tags: Exp Cell Res Source Type: research