Pregnancy - Related Heart Failure Tied to Higher Cancer Risk

Ninefold higher cancer occurrence seen both before and after peripartum cardiomyopathy diagnosis
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Cardiology, Family Medicine, Gynecology, Oncology, Pathology, Journal, Source Type: news

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Authors: Chua NK, Brown AJ Abstract Cholesterol synthesis is a fundamental process that contributes to cellular cholesterol homeostasis. Cells execute transcriptional and post-translational mechanisms to control the abundance of enzymes of the cholesterol synthesis pathway, consequently affecting cholesterol production. One such highly tuned enzyme is squalene monooxygenase (SM), which catalyzes a rate-limiting step in the pathway. A well-characterized mechanism is the cholesterol-mediated degradation of SM. Notably, lipids (cholesterol, plasmalogens, squalene, and unsaturated fatty acids) can act as cellular signa...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
1) incidence of prostate cancer is significantly declining 2) “Many [proton center] business plans require treating men diagnosed with prostate cancer in order to make the proforma financially viable” 3) The NCDB covers about... Prostate health
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums
This study examined placental pathology in women diagnosed with COVID-19 during pregnancy. What were the histopathologic findings, and what might be their impact on perinatal outcomes?American Journal of Clinical Pathology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news
Official data from mid-September shows that nearly 6,400 people had waited more than 100 days following a referral to cancer services.
Source: HSJ - Category: UK Health Source Type: news
Contributors : Xiaowei Wang ; Fangjia Tong ; Arlise Andress ; Gongyu Tang ; Ping LiuSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensExtracellular RNAs (exRNAs) have attracted great attention due to their essential role in cell-to-cell communication as well as their potential as non-invasive disease biomarkers. Recent studies have shown that exRNAs are associated with a variety of biological processes. Thus, the study of deregulated exRNAs would provide insight into disease progression. At present, there is no consensus on the best method to profile exRNA expression, which leads to...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Hee-Yeon Kim ; Hyonchol JangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGene expression profile in parental and cisplatin-resistant A549 cells
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
German cancer registry (Robert-Koch-Institute) data has shown a 16 fold risk of cancer in those with peripartum cardiomyopathy [1]. According to the report 21 of 236 patients had cancer, of which 12 had cancer diagnosed before peripartum cardiomyopathy. 11 of them had cardiotoxic chemotherapy. Of these, 17% fully recovered cardiac function compared to 55% of peripartum cardiomyopathy patients without cancer. Of the 10 patients who developed cancer after peripartum cardiomyopathy, 80% had left ventricular ejection fraction of 50% or more after cancer therapy. Authors mention that the high prevalence could be due to geneti...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardio Oncology Source Type: blogs
WEDNESDAY, Dec. 18, 2019 -- Patients with peripartum cardiomyopathy (PPCM) are more likely to have cancer before PPCM diagnosis and more likely to develop cancer after PPCM, according to a study published in the December issue of the JACC:...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
​BY JENNIFER TUONG; IVAN KHARCHENKO; JEAN LUC AGARD; &AHMED RAZIUDDIN, MDA 65-year-old man who had HIV well-controlled with highly active antiretroviral therapy, hypertension, sciatica, and restless leg syndrome presented to the emergency department with left leg pain. He also had had chemotherapy and radiation for anal cancer. The patient said the pain had started 45 minutes earlier when he was sitting on the toilet.He described the pain as sore in quality and 10/10 on the pain scale. He reported that it had started in his lower back and radiated to his left leg. He said he had had no trauma or weakness to the regio...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
Abstract Anthracycline-associated cardiomyopathy and peripartum cardiomyopathy are nonischemic cardiomyopathies that often afflict previously healthy young patients; both diseases have been well described since at least the 1970s and both occur in the settings of predictable stressors (ie, cancer treatment and pregnancy). Despite this, the precise mechanisms and the ability to reliably predict who exactly will go on to develop cardiomyopathy and heart failure in the face of anthracycline exposure or childbirth have proven elusive. For both cardiomyopathies, recent advances in basic and molecular sciences have illu...
Source: Circulation Research - Category: Cardiology Authors: Tags: Circ Res Source Type: research
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