One Hundred Years of Suramin.

One Hundred Years of Suramin. Antimicrob Agents Chemother. 2019 Dec 16;: Authors: Wiedemar N, Hauser DA, Mäser P Abstract Suramin is a hundred years old and still being used to treat the first stage of acute human sleeping sickness, caused by Trypanosoma brucei rhodesiense Suramin is a multifunctional molecule with a wide array of potential applications, from parasitic and viral diseases to cancer, snakebite and autism. Suramin is also an enigmatic molecule: What are its targets? And how does it get into cells in the first place? Here we provide an overview on the many different candidate targets of suramin, discuss modes of action, and routes of cellular uptake. We reason that once the polypharmacology of suramin is understood at the molecular level, new, more specific, and less toxic molecules can be identified for the numerous potential applications of suramin. PMID: 31844000 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research