Noggin inhibition of mouse dentinogenesis

ConclusionsThe phenotypes we observed in Noggin-overexpressing and Smad4-conditional knockout teeth resemble the phenotype of Dentinogenesis Imperfecta (DGI) type III. Our results show that BMPs regulate post-natal dentinogenesis and that BMP-inhibitory proteins like Noggin play a role in that regulation. The increased severity of the Smad4 phenotype indicates that Tgfß ligands, in addition to BMPs, play a crucial role in post-developmental dentinogenesis.
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research