Germline variants and response to systemic therapy in advanced prostate cancer

Pharmacogenomics,Volume 21, Issue 1, Page 75-81, January 2020.
Source: Future Medicine: Pharmacogenomics - Category: Genetics & Stem Cells Authors: Source Type: research

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We have read with interest the article by Qi et  al describing the results of a randomized trial testing 66 Gy versus 72 Gy for postoperative radiation therapy (RT) for prostate cancer with pathologic high-risk features (adjuvant RT) or biochemically recurrent prostate cancer patients after radical prostatectomy (salvage RT).1
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comments Source Type: research
Abstract The isomers of citral (cis-citral and trans-citral) were isolated from the Cymbopogon citratus (DC.) Stapf oil demonstrates many therapeutic properties including anticancer properties. However, the effects of citral on suppressing human prostate cancer and its underlying molecular mechanism have yet to be elucidated. The citral was isolated from lemongrass oil using various spectroscopic analyses, such as electron ionized mass spectrometry (EI-MS) and nuclear magnetic resonance (NMR) spectroscopy respectively. We carried out 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay to eval...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusions: Laserphyrin® and L-HVJ-E were distributed mainly in lysosomes and induced cell death by both apoptosis and necrosis. Furthermore, L-HVJ-E-mediated PDT effectively killed cultured PC-3 cells and exerted higher photocytotoxicity than Laserphyrin®-mediated PDT. PMID: 32255916 [PubMed]
Source: Laser Therapy - Category: Laser Surgery Tags: Laser Ther Source Type: research
Authors: Fan L, Wang H, Xia X, Rao Y, Ma X, Ma D, Wu P, Chen G Abstract [This corrects the article DOI: 10.3892/ol.2012.934.]. PMID: 32256830 [PubMed - as supplied by publisher]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: He Q, Chen K, Ye R, Dai N, Guo P, Wang L Abstract Ovarian cancer (OC) is the fifth most frequent cause of cancer-associated mortality worldwide, and is accompanied by asymptomatic progression. Sirtuins (SIRTs) are a family of nicotinamide adenine dinucleotide-dependent protein deacetylases, comprising seven members (SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6 and SIRT7). Accumulating evidence has demonstrated that SIRTs act as prognostic estimators in certain types of cancer such as lung cancer, prostate cancer, gastric cancer, breast cancer and colorectal cancer. However, it remains unknown whether individua...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Conclusions: The results of this analysis show differences between PBS and PS/US with regards to two-fold MID changes in urinary function at 12 months, but no differences for average score declines over time. Future studies evaluating PRO measures between the two PBT modalities are warranted. PMID: 32258443 [PubMed - as supplied by publisher]
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Clin Transl Radiat Oncol Source Type: research
Abstract The aim of the present study was to investigate the impact of the combined use of corticosteroid on adverse events (AEs) induced by enzalutamide (Enz) in patients with metastatic castration-resistant prostate cancer (mCRPC). The cohort of the present study included 121 consecutive patients with mCRPC who sequentially received androgen receptor-axis-targeted (ARAT) agents, abiraterone acetate (AA) and Enz, in any order, without prior docetaxel therapy. Detailed assessments of AEs during treatment with Enz were conducted according to whether or not corticosteroid was administered. Of these patients, 63 and ...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Mol Clin Oncol Source Type: research
Objectives The aim of this study was to evaluate the performance of an automated workflow for multiparametric magnetic resonance imaging (mpMRI) of the prostate compared with a manual mpMRI workflow. Materials and Methods This retrospective study was approved by the local ethics committee. Two MR technicians scanned 2 healthy volunteers with a prototypical highly automated workflow (Siemens Healthineers GmbH, Erlangen, Germany) and with a manually adjusted scan protocol each. Thirty patients (mean age ± standard deviation, 68 ± 11 years; range, 41–93 years) with suspected prostate cancer underwent ...
Source: Investigative Radiology - Category: Radiology Tags: Original Articles Source Type: research
Authors: Assoun EN, Meyer AN, Jiang MY, Baird SM, Haas M, Donoghue DJ Abstract Prostate cancer affects hundreds of thousands of men and families throughout the world. Although chemotherapy, radiation, surgery, and androgen deprivation therapy are applied, these therapies do not cure metastatic prostate cancer. Patients treated by androgen deprivation often develop castration resistant prostate cancer which is incurable. Novel approaches of treatment are clearly necessary. We have previously shown that prostate cancer originates as a stem cell disease. A prostate cancer patient sample, #87, obtained from prostatecto...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
In this study, we demonstrated by RT-qPCR analyses of 25 prostate tumors that hPCL3S is frequently up-regulated. In addition, hPCL3S is overexpressed in the androgen-independent DU145 and PC3 cells, but not in the androgen-dependent LNCaP cells. hPCL3S knockdown decreased the proliferation and migration of DU145 and PC3 whereas its forced expression into LNCaP increased these properties. A mutant hPCL3S unable to bind H3K36me3 (TUDOR-W50A) increased proliferation and migration of LNCaP similarly to wt hPCL3S whereas inactivation of its PHD1 domain decreased proliferation. These effects partially relied on the up-regulation...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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