Influenza A(H10N7) Virus in Dead Harbor Seals, Denmark

J. S. Krog et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research

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Publication date: Available online 12 October 2019Source: Veterinary MicrobiologyAuthor(s): Haiyan Sun, Jung-Hyang Sur, Sarah Sillman, David Steffen, Hiep L.X. VuAbstractThe substantial genetic diversity exhibited by influenza A viruses of swine (IAV-S) represents the main challenge for the development of a broadly protective vaccine against this important pathogen. The consensus vaccine immunogen has proven an effective vaccinology approach to overcome the extraordinary genetic diversity of RNA viruses. In this project, we sought to determine if a consensus IAV-S hemagglutinin (HA) immunogen would elicit broad protective ...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
In conclusion, a polypharmacology approach of combining established, prolongevity drug inhibitors of specific nodes may be the most effective way to target the nutrient-sensing network to improve late-life health. Deletion of p38α in Neurons Slows Neural Stem Cell Decline and Loss of Cognitive Function in Mice https://www.fightaging.org/archives/2019/10/deletion-of-p38%ce%b1-in-neurons-slows-neural-stem-cell-decline-and-loss-of-cognitive-function-in-mice/ Researchers here provide evidence for p38α to be involved in the regulation of diminished neural stem cell activity with age. It is thought...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsThe longstanding ethnopharmacological tradition of natural remedies against ARIs highlights their therapeutic impact and remains a highly valuable selection criterion for natural materials to be investigated in the search for novel anti-ARI acting concepts. We observe a tendency towards assaying for broad-spectrum antivirals and antibacterials mainly discovered in interdisciplinary academic settings, and ascertain a clear demand for more translational studies to strengthen efforts for the development of effective and safe therapeutic agents for patients suffering from ARIs.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 10 October 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Florent Valour, Anne Conrad, Florence Ader, Odile LaunaySummaryIn patients with chronic liver disease and liver transplant recipients, cirrhosis-associated immune dysfunction syndrome and immunosuppressant drug regimens required to prevent graft rejection lead to a high risk of severe infections, associated with acute liver decompensation, graft loss and increased mortality. In addition to maintain their global health status, vaccination represents a major preventive measure against specific infectiou...
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
Health officials say the flu season may complicate diagnosis of the lung damage from vaping, masking symptoms.
Source: NYT - Category: American Health Authors: Tags: Respiratory Diseases E-Cigarettes Evali Lungs Deaths (Fatalities) Centers for Disease Control and Prevention your-feed-healthcare Influenza Source Type: news
Authors: Tolan HEM, El-Sayed WA, Tawfek N, Abdel-Megeid FME, Kutkat OM Abstract New 1,2,3-triazole glycosides and 1,2,4-thioglycosides incorporating a substituted pyrimidinedione ring system were synthesized via click dipolar cycloaddition and heterocyclization of hydrazine-1-carbodithioate derivatives, respectively. The sugar hydrazine derivatives linked aminodimethyluracil were also prepared. In addition, the oxadiazoline substituted with acyclic sugar moieties linked to the pyrimidinedione as acyclic nucleoside analogs were synthesized. The antiviral activity of the synthesized compounds against avian influenza ...
Source: Nucleosides, Nucleotides and Nucleic Acids - Category: Biochemistry Tags: Nucleosides Nucleotides Nucleic Acids Source Type: research
THE FLU JAB is free on the NHS to vulnerable people this winter, as cases of the influenza virus steadily increase in the winter months. Pursuant myths surround the jab wrongly dissuade some people from getting the protection they need.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
FRIDAY, Oct. 11, 2019 -- The risk for hospitalization with pandemic influenza is higher for patients with type 2 diabetes than for those without type 2 diabetes, according to a study published online Oct. 6 in the Journal of Internal Medicine. Paz...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
The objective of this study was to obtain a detailed picture of the transmission dynamics of seasonal influenza in Switzerland from 2003 to 2015. To this end, we developed a compartmental influenza transmission model taking into account social mixing between different age groups and seasonal forcing. We applied a Bayesian approach using Markov chain Monte Carlo (MCMC) methods to fit the model to the reported incidence of influenza-like-illness (ILI) and virological data from Sentinella, the Swiss Sentinel Surveillance Network. The maximal basic reproduction number, R0, ranged from 1.46 to 1.81 (median). Median estimates of...
Source: Epidemics - Category: Epidemiology Source Type: research
Publication date: Available online 10 October 2019Source: Journal of Hospital InfectionAuthor(s): Alexandra Peters, Ellen Frat, Anne Iten, Julien Sauser, Manuel Schibler, Didier Pittet
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
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