Women's reproductive lifespan and subsequent inflammatory profile, how to best measure reproductive lifespan and the need for baseline assessments.

Women's reproductive lifespan and subsequent inflammatory profile, how to best measure reproductive lifespan and the need for baseline assessments. Am J Epidemiol. 2019 Dec 17;: Authors: Schliep KC Abstract Inflammatory processes are known to drive the pathogenesis of several chronic diseases, including cardiovascular disease, Alzheimer's disease, and all-cause mortality. Emerging research indicates that women who have a longer reproductive lifespan, roughly age of menarche to age of menopause or lifetime ovulatory cycles after accounting for anovulatory timespans, are at lower risk for these same inflammation-related chronic diseases. The paradox is that ovulation is known to induce acute inflammation. Given the limited research that has assessed the relationship between reproductive lifespan and later inflammatory profiles, Huang et al., set out to investigate this relationship within one of the most robust women's longitudinal cohorts-the Nurses' Health Studies. The authors found that after adjusting for other inflammation-related factors including adiposity, exercise, and diet, lifetime ovulatory years was associated with lower C-reactive protein in both premenopausal and postmenopausal women. The paper by Huang et al. calls to attention several challenges in women's reproductive lifespan research including how to appropriately capture lifetime ovulatory cycles and the need for repeated measures of inflammatory biomarkers across the lifecourse if we ...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research

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Contributors : Tutu Oyelami ; An De Bondt ; Ilse Van den Wyngaert ; Kirsten Van Hoorde ; Ilse Dewachter ; John KempSeries Type : Expression profiling by arrayOrganism : Mus musculusThe prevalence of Alzheimer ’s disease is significantly higher in women than in men, with recent estimates suggesting that two thirds of AD patients are females. However, the reason for this is unclear and complex, with the fact that women live longer than men being a likely contributor to the observed disparity. Given the c omplexity of AD and the restrictions in studying any gender-linked biological differences in patients, an establishe...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Authors: Marotta F, Marcellino M, Catanzaro R, Campiotti A, Lorenzetti A, Cervi J, Barbagallo M Abstract During the menopause women may experience increased oxidative stress and decreased antioxidant capacity and, together with the decline of neurosteroids, this represents a risk factor for Alzheimer's disease. The aim of the present study was to test a functional food (FPP-ORI, Osato Research Institute, Gifu, Japan) on redox and mitochondrial efficiency in post-menopausal women. The study population consisting of 69 untreated post-menopausal women were given supplements as follows: Group A was given a multivitamin...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Experts examined if brain fog experienced in menopause could be related to Alzheimer's disease. Helen Smith almost left her job at Greater Manchester Police due to the symptom.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 11 February 2020Source: Pharmacological ResearchAuthor(s): Minghua Wu, Min Li, Jun Yuan, Sen Liang, Zhaoyao Chen, Min Ye, Paul M. Ryan, Cain Clark, Shing Cheng Tan, Jamal Rahmani, Hamed kord Varkaneh, Akshaya Srikanth BhagavathulaAbstractHormone therapy continues to be a favourable option in the management of menopausal symptomatology, but the associated risk-benefit ratios with respect to neurodegenerative diseases remain controversial. The study aim was to determine the relation between menopausal hormone therapy and Alzheimer's disease, dementia, and Parkinson's disease in human subjec...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
In conclusion, this study suggests that epigenetic age acceleration is significantly associated with lung function in women older than 50 years. We hypothesised that this could be due to menopause. However, we have observed that menopause has minimal effect and therefore there is possibility of other unknown physiological factors at older age in females mediating the epigenetic age acceleration effect on lung function. While, it is still unknown what exactly epigenetic aging from DNA methylation measures, this study suggests it can be utilised as one of the important factors to assess women's lung health in old age. DNA me...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract 17β-Estradiol (estradiol or E2) is a steroid hormone that has been broadly applied as a neuroprotective therapeutic for a variety of neurodegenerative and cerebrovascular disorders such as ischemic stroke, Alzheimer's disease, and Parkinson's disease. Several laboratory and clinical studies have reported that estrogen replacement therapy (ERT) had no effect against these diseases in elderly postmenopausal women, and at worst, increased their risk of onset and mortality. This review focuses on the growing body of data from in vitro and animal models characterizing the potential underlying mechanisms a...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research
Conclusion: Our data support a precision medicine approach for further development of PhytoSERM as a safe and effective alternative to hormone therapy for menopause-associated hot flash and cognitive decline. While definitive determination of PhytoSERM efficacy is limited by the small sample size, these data provide a reasonable rationale to extend analyses to a larger study set powered to address statistical significance.
Source: Menopause - Category: OBGYN Tags: Original Studies Source Type: research
Conclusions: Our results suggest that longer EEE and HT use, especially in older women, are associated with higher cognitive status in late life.
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
Neuroscience biopharmaceutical company Aprinoia Therapeutics has announced...Read more on AuntMinnie.comRelated Reading: fMRI shows dementia patients' brain response to music New Alzheimer's definition relies on imaging biomarkers DTI-MRI ties lack of fitness to cognitive decline Flortaucipir-PET could lead in early Alzheimer's detection PET study links menopausal status to Alzheimer's
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Abstract Alzheimer's disease and other forms of cognitive decline are significantly more prevalent in post-menopausal women. Decreased estrogen levels, due to menopause or ovariectomy, may contribute to memory impairments and neurodegeneration. Another result of decreased estrogen levels is elevated luteinizing hormone (LH). Elevated LH after menopause/ovariectomy has been shown to impair cognition in both human and animal studies. Lowering LH levels rescues spatial memory in ovariectomized (ovx) rodents, yet the mechanisms of these effects are still unclear. Estrogens appear to exert some of their effects on memo...
Source: Hormones and Behavior - Category: Endocrinology Authors: Tags: Horm Behav Source Type: research
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