Commentary: Estimated Lifetime Ovulatory Years and Its Determinants in Relation to Circulating Inflammatory Markers.

Commentary: Estimated Lifetime Ovulatory Years and Its Determinants in Relation to Circulating Inflammatory Markers. Am J Epidemiol. 2019 Dec 17;: Authors: Schildkraut JM Abstract In this issue of the American Journal of Epidemiology, Huang et al. report an inverse relationship between lifetime ovulatory cycle years (LOY) and circulating C-reactive protein (CRP), counter to their hypothesis. CRP is a non-specific systemic marker of chronic inflammation and there is evidence that there are other drivers of systemic inflammation as measured by CRP. There also is a body of evidence supporting that ovulation may be responsible for a localized inflammatory response. As ovarian cancer is the fifth most common cause of cancer death in women, preventive strategies are urgently needed. The findings of this report underscore the need for new research initiatives to determine the relationship between incessant ovulation and ovarian cancer risk in order to identify mechanisms of carcinogenesis that will lead to the prevention of this disease. PMID: 31845738 [PubMed - as supplied by publisher]
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research

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Abstract Ovarian cancer is one of the most fatal cancers diagnosed in women in the United States (U.S.). Data from national databases, including the Surveillance Epidemiology and End Results (SEER) program, show racial/ethnic differences in risk and survival of epithelial ovarian cancer with higher incidence among white women yet worse survival among African-American women compared to other racial/ethnic groups. The reasons for these differences are not well understood, but are likely multi-factorial. Epidemiologic studies suggest there may be some risk factor differences across racial/ethnic groups that would exp...
Source: Advances in Cancer Research - Category: Cancer & Oncology Authors: Tags: Adv Cancer Res Source Type: research
In conclusion, the results of the present study provided a new underlying mechanism of the effect of EGCG on ovarian cancer and may lead to the development of EGCG as a candidate drug for ovarian cancer therapy. PMID: 32236585 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Publication date: Available online 2 April 2020Source: Stem Cell ReportsAuthor(s): Nina Maenhoudt, Charlotte Defraye, Matteo Boretto, Ziga Jan, Ruben Heremans, Bram Boeckx, Florian Hermans, Ingrid Arijs, Benoit Cox, Els Van Nieuwenhuysen, Ignace Vergote, Anne-Sophie Van Rompuy, Diether Lambrechts, Dirk Timmerman, Hugo Vankelecom
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
AbstractThe field of genetic counseling in India has enormously transformed over the past few years. Genetic counseling is a communication process which deals with the human problems associated with the occurrence or risk of occurrence of a genetic disorder in a family. Genetic counseling is not merely having a conversation based on genomic data. It addresses the “information needs” of a particular patient, and customizes a session according to each patient’s individual circumstances, thereby aiding in decision-making. In 2012, AIIMS (New Delhi) became the first tertiary care center in North India to prov...
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
;ndez-de Fernández-de Thomas Pablo E. Vivas-Mejía Despite good responses to first-line treatment with platinum-based combination chemotherapy, most ovarian cancer patients will relapse and eventually develop platinum-resistant disease with poor prognosis. Although reports suggest that integrin-linked kinase (ILK) is a potential target for ovarian cancer treatment, identification of ILK downstream effectors has not been fully explored. The purpose of this study was to investigate the molecular and biological effects of targeting ILK in cisplatin-resistant ovarian cancer. Western blot analysis showed that...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Survival of patients with advanced ovarian cancer continues to increase, despite concerns that increased use of neoadjuvant chemotherapy (NAC) could have a negative impact on outcomes.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05121
Source: Analytical Chemistry - Category: Chemistry Authors: Source Type: research
Contributors : Mengnan Zhang ; Yuehua Wang ; Lilya V Matyunina ; Amber Akbar ; John F McDonaldSeries Type : Expression profiling by arrayOrganism :Recent years have witnessed a dramatic increase in our appreciation of the contribution of microRNAs (miRNAs) to cancer onset and progression. As a consequence, there has been growing interest in the development of miRNAs not only as diagnostic biomarkers of cancer but also as a promising new class of therapeutic agents. Over the last several years, our laboratory has focused on analysis of the molecular processes underlying the ability of individual miRNAs to induce mesenchymal...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research
Chemotherapy and/or radiotherapy treatments may cause premature ovarian failure and irreversible loss of fertility. In the context of childhood cancers, it is now acknowledged that possible negative effects of...
Source: BMC Medical Ethics - Category: Medical Ethics Authors: Tags: Research article Source Type: research
Epithelial ovarian cancers (EOCs) comprises the majority of malignant ovarian neoplasms. Combination treatment with chemotherapeutic agents seems to be a promising strategy in ovarian cancer (OVCA) patients in...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
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