Ferumoxytol-enhanced cardiovascular magnetic resonance detection of early stage acute myocarditis

This study examined whether ferumoxytol-enhanced CMR (FE-CMR) could detect an earlier stage ...
Source: Journal of Cardiovascular Magnetic Resonance - Category: Radiology Authors: Tags: Research Source Type: research

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Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly utilized in the setting of cardiogenic shock to provide hemodyamic and respiratory support to the acutely decompensating patient. Common scenarios include cardiogenic shock following acute myocardial infarction, acute exacerbation of chronic congestive heart failure, myocarditis, and postcardiotomy shock among others.1 This extremely aggressive therapy can be life-saving when appropriately applied, but inappropriate use can lead to unnecessary prolongation of patient and family suffering and significant costs and resource utilization.
Source: Heart and Lung - Category: Intensive Care Authors: Source Type: research
Authors: Kim MJ, Hong GR, Ha JW, Shim CY PMID: 32212424 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
Conclusions: SPECT/CT-based quantitative assessment of 99mTc-Pyrophosphate accumulation in the myocardium is a highly informative noninvasive method for diagnosis of inflammatory process in the heart in patients with AF of undefined etiology. PMID: 32211203 [PubMed]
Source: Cardiology Research and Practice - Category: Cardiology Authors: Tags: Cardiol Res Pract Source Type: research
Publication date: April 2020Source: Medicina Intensiva (English Edition), Volume 44, Issue 3Author(s): S. Bobillo-Perez, J. Sanchez-de-Toledo, S.S. Matute, M. Balaguer, I. Jordan, J. Rodriguez-Fanjul
Source: Medicina Intensiva - Category: Intensive Care Source Type: research
In this study, we identified the lncRNA AK085865 as an important regulator of macrophage polarization. Knock-down of AK085865 diminished phenotypical expression of M2 macrophages while promoting polarization to the M1 phenotype. Moreover, AK085865-/- mice had increased susceptibility to CVB3-induced VM. We observed striking bias towards M1 macrophages, whereas the M2 population was decreased in AK085865-/- VM mice. Collectively, our findings uncover a critical role of AK085865 in the regulation of macrophage polarization in vitro and in vivo, identifying a new player in the development of VM and providing a potential clini...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
Myocarditis is a polymorphic disease complicated with indeterminate etiology and pathogenesis, and represents one of the most challenging clinical problems lacking specific diagnosis and effective therapy. It is caused by a complex interplay of environmental and genetic factors, and causal links between dysregulated microribonucleic acids (miRNAs) and myocarditis have also been supported by recent epigenetic researches. Both dysregulated CD4+ T cells and miRNAs play critical roles in the pathogenesis of myocarditis, and the classic triphasic model of its pathogenesis consists of the acute infectious, subacute immune, and r...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conditions:   COVID-19;   Myocardial Injury;   Myocarditis Intervention:   Diagnostic Test: Electrocardiogram and transthoracic echocardiography Sponsor:   Groupe Hospitalier Pitie-Salpetriere Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Discussion Tachycardia is a rapid heart rate that is above normal for age and level of exertion. Tachycardia is common, particularly sinus tachycardia due to normally encountered circumstances such as pain, fever or exercise. It is usually a normal physiologic process but sustained tachycardia often indicates a potentially abnormal underlying cause. Sinus tachycardia has a rapid heart rate with normal P waves and P-R intervals and variations from moment to moment and respiration. Generally it is not over 200 beats/minute. Vagal stimulation can slow the heart rate; this is a gradual slowing, not an abrupt slowing seen in ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Publication date: Available online 20 March 2020Source: Journal of Critical CareAuthor(s): Heng-Wen Chou, Chih-Hsien Wang, Lian-Yu Lin, Nai-Hsin Chi, Nai-Kuan Chou, Hsi-Yu Yu, Yih-Sharng Chen
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
This study aimed to report the long‐term outcomes and clinical management following LVAD explantation.Methods and resultsAn analysis of the European Registry for Patients with Mechanical Circulatory Support was performed to identify all adult patients with myocardial recovery and successful explantation. Pre ‐implant characteristics were retrieved and compared with the non‐recovery patients. The follow‐up data after explantation were collected via a questionnaire. A Kaplan–Meier analysis for freedom of the composite endpoint of death, heart transplantation, LVAD reimplantion, or heart failure (H F) relapse wa...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
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