Frailty index and phenotype frailty score: sex- and age-related differences in 5XFAD transgenic mouse model of Alzheimer’s disease

Publication date: Available online 16 December 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Smilja Todorovic, Natasa Loncarevic-Vasiljkovic, Milena Jovic, Srdjan Sokanovic, Selma Kanazir, Aleksandra Mladenovic DjordjevicAbstractAlzheimer’s disease patients (AD), as well as AD transgenic mice, are characterized by increased frailty. Furthermore, the assessment of frailty status represents a feasible approach for detecting individuals prone to develop more severe form of AD and for measuring the outcome of existing and putative AD therapeutics. The 5xFAD mouse is one of the widely used transgenic animal models of AD, but frailty in this model is scantly investigated. We used two validated mouse frailty assessment tools: phenotypic frailty score (FS) and clinical frailty index (FI) to investigate age- and sex- related differences in frailty status in 5xFAD mice. These tools measure different age-related deficits and do not necessarily identify the same subpopulations as frail. We detected a significant increase in frailty with age in both sexes, although females were surprisingly less frail than males. Depending on the tools used, a notable difference in frailty status was detected, with frailty index and frailty score identifying different mice as frail. These results warrant great caution when choosing the frailty tool and point to the need for further adaptation of frailty measurements in mouse models of AD.
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research

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Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00928H, CommunicationHao Shao, Keely Oltion, Taia Wu, Jason E. Gestwicki Homo-oligomers are difficult drug targets. Here, Differential Scanning Fluorimetry (DSF) is introduced as a method to identify inhibitors of these systems, by discriminating between oligomers and monomers based on their thermal stability. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
CONCLUSIONS: VCE is useful for the diagnosis of MD and should be used as a valuable and less invasive examination to confirm or establish a diagnosis. PMID: 32450705 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
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Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Authors: Parikh AM, Grogan RH, Morón FE Abstract The localization of persistent or recurrent disease in reoperative patients with primary hyperparathyroidism presents challenges for radiologists and surgeons alike. In this article, we summarize the relevant imaging modalities, compare their accuracy in identifying reoperative disease, and outline their advantages and disadvantages. Accurate localization by preoperative imaging is a predictor of operative success, whereas negative or discordant preoperative imaging is a risk factor for operative failure. Ultrasound is a common first-line modality because it i...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Authors: Kosone T, Takagi H, Takakusagi S, Hoshino T, Yokoyama Y, Kizawa K, Marubashi K, Watanabe A, Araki K, Harimoto N, Ikota H, Shirabe K, Harada K, Kakizaki S, Uraoka T Abstract We experienced a case of follicular cholangitis that was positive on fluorodeoxyglucose-positron emission tomography (18F-FDG-PET). A 70-year-old man was admitted for jaundice. Endoscopic retrograde cholangiography showed stenosis of the middle to upper choledocus. 18F-FDG-PET depicted a localized hot spot at the stenotic lesion (maximum standardized uptake value = 8.2). Although no malignant findings were found in the cytology or on a ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Despite renewed interests in the labeling perspective and the impact of official intervention on individuals' future outcomes, scant attention has been given to potential conditioning factors for theorized labeling processes. We argue that, when viewed thr...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Raymond-Pope, CJ, Dengel, DR, Fitzgerald, JS, and Bosch, TA. Association of compartmental leg lean mass measured by dual X-ray absorptiometry with force production. J Strength Cond Res 34(6): 1690–1699, 2020—We recently reported a novel method for measuring upper leg anterior/posterior compartmental composition. The purpose of this study was to determine the association of this method with measures of muscle-specific and explosive strength and to compare this method with traditional dual energy X-ray absorptiometry (DXA) measurements of total and upper leg masses. We hypothesize this method will be related to m...
Source: Journal of Strength and Conditioning Research - Category: Sports Medicine Tags: Original Research Source Type: research
Condition:   Alzheimer Disease Interventions:   Other: nocturnal polysomnography (NPSG);   Procedure: Lumbar Puncture (LP);   Procedure: MRB PET-MR scan Sponsors:   NYU Langone Health;   National Institute on Aging (NIA) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Most of us know helium as the gas that makes balloons float, but the second element on the periodic table does much more than that. Helium pressurizes the fuel tanks in rockets, helps test space suits for leaks, and is important in producing components of electronic devices. Magnetic resonance imaging (MRI) machines that take images of our internal organs can’t function without helium. And neither can nuclear magnetic resonance (NMR) spectrometers that researchers use to determine the structures of proteins—information that’s important in the development of medications and other uses. Helium&rsq...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - Category: Research Authors: Tags: Chemistry, Biochemistry and Pharmacology Tools and Techniques Cool Tools/Techniques Scientific Process Source Type: blogs
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Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research
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