Test-retest reliability, internal consistency, construct validity and factor structure of a falls risk perception questionnaire in older adults with type 2 diabetes mellitus: a prospective cohort study - Gravesande J, Richardson J, Griffith L, Scott F.

BACKGROUND: Older adults with type 2 diabetes (DM2) are at increased risk of falling due to complications including: diabetic peripheral neuropathy, diabetic retinopathy, autonomic neuropathy and diabetic foot ulcers. The purpose of this study was to deter...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

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J Am Podiatr Med Assoc. 2021 Jul 1;111(4):Article_8. doi: 10.7547/18-178.ABSTRACTBACKGROUND: Ankle position sense may be reduced before the appearance of the clinical manifestation of diabetic peripheral neuropathy. This is known to impair gait and cause falls and foot ulcers. Early detection of impaired ankle proprioception is important because it allows physicians to prescribe an exercise program to patients to prevent foot complications.METHODS: Forty-six patients diagnosed as having type 2 diabetes mellitus and 22 control patients were included in the study. Presence of neuropathy was assessed using the Michigan Neurop...
Source: Journal of the American Podiatric Medical Association - Category: Podiatry Authors: Source Type: research
CONCLUSION: Four prediction models were established to assist with the early screening of DPN in patients with T2DM. The influencing factors in model C and D are more important factors for patients with T2DM diagnosed with DPN.PMID:34352988 | DOI:10.4093/dmj.2020.0100
Source: Diabetes and Metabolism Journal - Category: Endocrinology Authors: Source Type: research
AbstractPurposeDiabetic foot ulcer (DFU) is a common chronic complication of type 2 diabetes mellitus (T2DM) in Indonesia, with a prevalence of 7.3%. However, the characteristics of these patients remain unclear. We investigated the characteristics of patients with DFU without peripheral arterial disease (PAD) and analyzed non-vascular factors related to severity of DFU in a tertiary care national referral hospital in Indonesia.MethodsThis was a cross-sectional study including 123 hemodynamically stable DFU patients without PAD recruited from Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia from 2010 &n...
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
This study aimed to assess the prevalence of DPN and its risk factors among the type 2 DM patients attending a rural health centre.MethodologyA cross-sectional study was conducted among 390 type 2 DM patients attending the Rural Health and Training Centre of Sri Ramachandra Medical College&Research Institute. Data was collected using a standardized questionnaire followed by general inspection and physical examination of the feet. Blood sample was taken to estimate HbA1c and urine sample was collected to detect presence of albumin.ResultsAmong the 390 participants, 175 (44.9%) had neuropathy of which 87 (51.5%) were sym...
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
Abstract MicroRNAs represent a class of small (19-25 nucleotides) single-strand pieces of RNA, that are non-coding ones. They are synthesized by RNA polymerase II from transcripts which fold back on themselves. They mostly act as gene regulatory agents, that pair with complementary sequences on mRNA and produce silencing complexes, which in turn suppress coding genes at a post-transcriptional level. There is now evidence that microRNAs may affect insulin secretion or insulin action, as they can alter pancreatic beta cells development, insulin production, as well as insulin signalling. Any molecular disorder that a...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Diabetic foot is one of the dreaded complications of diabetes mellitus (DM). Alterations of the Achilles tendon (AT) may contribute to development of foot ulcers in diabetic patients. We evaluated the sonoelastographic abnormalities of the AT in 61 healthy volunteers and 81 patients with type 2 DM. The patients were further divided into those with and without peripheral neuropathy (PN). The AT thickness was measured in the proximal, middle and distal portions. Alterations in echo pattern were noted.
Source: Ultrasound in Medicine and Biology - Category: Radiology Authors: Tags: Original Contribution Source Type: research
This study aimed to determine financial burden and risk factors associated with T2DM-related foot amputation. METHODS: Retrospective hospital-based study from January 2017 to December 2018. Patients with T2DM with and without amputation were enrolled. The direct medical costs of amputation along with various risk factors were determined. Risk factors were evaluated by logistic regression analysis. RESULTS: A total 1460 patients with T2DMwere included; 484 (33%) patients had an amputation. Mean total cost of below knee, fingers and toe amputation were 886.63±23.91, 263.35 ±19.58 and 166.68 ± 8...
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research
Diabetic peripheral neuropathy (DPN) is the most common chronic complication of type 2 diabetes mellitus (T2DM), affecting almost 50% patients with T2DM [1]. It is widely considered as a major risk factor for foot ulcers and lower-extremity amputations [2]. Approximately 70% of patients with DPN die at the age of 10 years after the initial diagnosis of DPN, with 50% of these deaths being cardiovascular related [3]. The number of people with diabetes and the burden of DPN have increased with the aging of the population.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
This study aimed to compare the effect of high-intensity interval training (HIIT) with moderate-intensity continuous training (MCT) on endothelial function, oxidative stress and clinical fitness in patients with type 1 diabetes. Thirty-six type 1 diabetic patients (mean age 23.5 ± 6 years) were randomized into 3 groups: HIIT, MCT, and a non-exercising group (CON). Exercise was performed in a stationary cycle ergometers during 40 min, 3 times/week, for 8 weeks at 50–85% maximal heart rate (HRmax) in HIIT and 50% HRmax in MCT. Endothelial function was measured by flow-mediated dilation (FMD) [endothelium-depende...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
The objectives of this study were to examine the effectiveness of different types of exercise on risk factors of diabetic foot ulcers, including glycated hemoglobin, peripheral arterial disease, and diabetic peripheral neuropathy, in people with type 2 diabetes mellitus. PubMed, Web of Science, Cochrane Library, Scopus, and CINAHL were searched from inception to January 2018 for relevant articles. Eligible studies were randomized controlled trials that examined effects of exercise on the selected risk factors. Twenty randomized controlled trials with 1357 participants were included in the meta-analyses. The differences in ...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
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