Macrophage-Mediated Bystander Effects after Different Irradiations through a p53-dependent Pathway.

In conclusion, the bystander lymphoblast damage was induced in different cells using different LET radiations. An amplified bystander response was modulated by the intermediator macrophage. The underlying molecular mechanisms of these bystander effects were dependent on the activation of p53 and its relevant apoptosis pathway in the irradiated cells. These results suggest that the bystander and macrophage-mediated bystander effects contribute to the common acute side effect of lymphocytopenia after local irradiation. PMID: 31841081 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31841081?dopt=Abstract

Source: Radiation Research - December 15, 2019 Category: Physics Authors: Fu J, Zhu L, Tu W, Wang X, Pan Y, Bai Y, Dang B, Chen J, Shao C Tags: Radiat Res Source Type: research

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