Activation of immunosuppressive network in the aging process.
Activation of immunosuppressive network in the aging process. Ageing Res Rev. 2019 Dec 12;:100998 Authors: Salminen A Abstract Chronic low-grade inflammation has a key role in the aging process, a state called inflammaging. It is known that the chronic inflammatory condition generates counteracting immunosuppressive state in many diseases. Inflammaging is also associated with an immune deficiency; generally termed as immunosenescence, although it is not known whether it represents the senescence of immune cells or the active remodeling of immune system. Evidence has accumulated since the 1970's indicating that immunosenescence might be caused by an increased activity of immunosuppressive cells rather than cellular senescence. Immune cells display remarkable plasticity; many of these cells can express both proinflammatory and immunosuppressive phenotypes in a context-dependent manner. The immunosuppressive network involves the regulatory subtypes of T (Treg) and B (Breg) cells as well as regulatory phenotypes of macrophages (Mreg), dendritic (DCreg), natural killer (NKreg), and type II natural killer T (NKT) cells. The immunosuppressive network also includes monocytic (M-MDSC) and polymorphonuclear (PMN-MDSC) myeloid-derived suppressor cells which are immature myeloid cells induced by inflammatory mediators. This co-operative network is stimulated in chronic inflammatory conditions preventing excessive inflammatory responses but at the same time they exer...
Authors: Messaadi N, Bayen S, Beghin L, Lefebvre JM, Colleau S, Deken V, Cottencin O, Quersin F, Descamps A, Vanhelst J Abstract BACKGROUND: Screen media usage has become increasingly commonplace in daily life with children initiating themselves to screen media at an early age. Given the high prevalence of screen viewing among children worldwide, its impact on children's health has become a cause for concern. Unfortunately, little information on the independent association between sleep habits and screen time in French children is currently available. The main aim of this study was to assess possible...
Publication date: Available online 28 May 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Aline Bayerle, Christian Marsching, Mariona Rabionet, Shaalee Dworski, Mustafa A. Kamani, Chandramohan Chitraju, Nina L. Gluchowski, Katlyn R. Gabriel, Silke Herzer, Richard Jennemann, Thierry Levade, Jeffrey A. Medin, Roger Sandhoff
PMID: 32464083 [PubMed - as supplied by publisher]
Conclusions: EVs from buffaloes infected with Theileria spp. were successfully isolated and characterized. This is an advance in the knowledge of host-parasite relationship that contributes to the understanding of host immune response and theileriosis evasion mechanisms. These findings may pave the way for searching new EVs candidate-markers for a better production of safe biological products derived from buffaloes.
Conclusions: JZTX-X selectively suppresses Kv4.2 and Kv4.3 potassium channe l activity in a concentration- and voltage-dependent manner and causes long-lasting mechanical hyperalgesia.
Conclusion: Our results suggest a different biochemical composition of S. polymorpha venom, based on the different effects of four venom fractions on the cells tested, according to statistical evidence. Fractions F6 and F7 caused the most important alterations.
Publication date: Available online 29 May 2020Source: The Annals of Thoracic SurgeryAuthor(s): Irsa S. Hasan, Hartzell V. Schaff, Richard C. Daly, Katherine S. King, John M. Stulak, Kevin L. Greason, Joseph A. Dearani
Publication date: Available online 29 May 2020Source: The Annals of Thoracic SurgeryAuthor(s): Takafumi Ouchi, Noriyuki Kato, Hiroaki Kato, Takatoshi Higashigawa, Hisato Ito, Ken Nakajima, Shuji Chino, Toshiya Tokui, Toru Mizumoto, Hajime Sakuma
Publication date: September 2020Source: Interdisciplinary Neurosurgery, Volume 21Author(s): Nobuya Murakami, Takato Morioka, Satoshi O. Suzuki, Nobutaka Mukae, Takafumi Shimogawa, Yoshihiro Matsuo, Takakazu Sasaguri, Masahiro Mizoguchi
Publication date: September 2020Source: Interdisciplinary Neurosurgery, Volume 21Author(s): Zachary K. Christian, Kimmo J. Hatanpaa, Richard J. Auchus, Stephen R. Hammes, Ankur R. Patel, Bruce E. Mickey