Adaptation of the Clinical Dementia Rating Scale for adults with Down syndrome

ConclusionsThe modified questionnaire and interview instruments capture a range of impairment in DS adults, including subthreshold symptomatology, and the instruments provide complementary information relevant to the ascertainment of dementia in DS. Decline was seen across all cognitive domains and was generally positively related to age and negatively related to IQ. Most importantly, adjusting instrument scores for chronic, premorbid impairment drastically shifted the distribution toward lower (no impairment) scores.
Source: Journal of Neurodevelopmental Disorders - Category: Neurology Source Type: research

Related Links:

Authors: Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC Abstract OBJECTIVE: Recent clinical trials targeting amyloid beta (Aβ) and tau in Alzheimer's disease (AD) have yet to demonstrate efficacy. Reviewing the hypotheses for AD pathogenesis and defining possible links between them may enhance insights into both upstream initiating events and downstream mechanisms, thereby promoting discovery of novel treatments. Evidence that in Down syndrome (DS), a population markedly predisposed to develop early onset AD, increased APP gene dose is necessary for both AD neuropat...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
PET imaging could be a useful tool for diagnosis and treatment of idiopathic...Read more on AuntMinnie.comRelated Reading: FDG levels show link between Alzheimer's, Down syndrome SNMMI 2020: Image of the Year scans reveal 'super-agers' New tau PET tracer better targets source of Alzheimer's New PET technique visualizes early Alzheimer's disease PET tracer could more precisely diagnose Alzheimer's
Source: Headlines - Category: Radiology Source Type: news
We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze), but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit. Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the genes that were unique...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Researchers Detangle Protein Interaction Implicated in Down Syndrome and Alzheimer's New findings by chemists Wolfgang Peti and Rebecca Page provide a foundation to better understand and treat these neurological disorders. Brittany Uhlorn Today BIO5 InstituteNMR_room_PC Wolfgang Peti-web.jpg The powerful biomolecular NMR spectrometers at the University of Arizona have allowed scientists to gain molecular details of the interaction between RCAN1 and calcineurin, two proteins that have long been implicated in Down syndrome and Alzheimer's disease.HealthScience and TechnologyBIO5College of ScienceMedia contact...
Source: The University of Arizona: Health - Category: Universities & Medical Training Authors: Source Type: research
This study revealed that the amyloid assembly is mediated via binding-induced conformational switching into an early partially helical amyloid-competent intermediate. Additionally, protein and inducer concentration-dependent studies indicated that at the higher protein and/or inducer concentrations, competing off-pathway intermediates dampen the amyloid assembly which implies that the stoichiometry of protein and inducer plays a key regulatory role in the amyloid nucleation and fibril elongation kinetics. PMID: 32691116 [PubMed - as supplied by publisher]
Source: European Biophysics Journal : EBJ - Category: Physics Authors: Tags: Eur Biophys J Source Type: research
This study tests the hypothesis that identifying IFN-stimulated response element (ISRE) control sites on Ch21 will mark novel candidate genes for DS/T21-related IFN hypersensitivity and neuropathology not previously reported to be associated with IFN functions. We performed whole chromosome searches of online databases. The general ISRE consensus and gamma interferon activation consensus sequences (GAS) were used for identifying IFN-stimulated response elements. Candidate genes were defined as those possessing two or more ISRE and/or GAS control sites within and/or upstream of the transcription start site. A literature sea...
Source: Autoimmune Diseases - Category: Allergy & Immunology Tags: Autoimmune Dis Source Type: research
This article provides a summary of discussions, including noting areas of emerging science and discovery, considerations for future studies, and identifying open gaps in our understanding for future focus. PMID: 32544310 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
AbstractIndividuals with Down syndrome (DS) are at high risk for developing Alzheimer ’s disease (AD) pathology and this has provided significant insights into our understanding of the genetic basis of AD. The present review summarizes recent clinical, neuropathologic, imaging, and fluid biomarker studies of AD in DS (DSAD), highlighting the striking similarities, as well as some n otable differences, between DSAD and the more common late-onset form of AD (LOAD) in the general population, as well as the much rarer, autosomal-dominant form of AD (ADAD). There has been significant progress in our understanding of the n...
Source: CNS Drugs - Category: Neurology Source Type: research
218Background: Adults with Down syndrome (DS) are predisposed to Alzheimer’s disease (AD), with most developing clinical dementia by their late 60s. While Aβ pathology has been previously characterized in this population, its relationship with neurofibrillary tau is much less well understood. Objectives: The focus of this study is to determine the associations between global Aβ and regional tau in DS, as well as assess the differences in these biomarkers between cognitively stable adults with DS (CS) and cases of cognitive impairment (MCI/AD). Methods: A total of 140 adults with DS (age = 39.3 ± 8.4 ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Science - Inflammation and Dementia Source Type: research
Cortical laminar distribution of β-amyloid deposits in five neurodegenerative disorders. Folia Neuropathol. 2020;58(1):1-9 Authors: A Armstrong R Abstract Alzheimer's disease neuropathologic change (ADNC) in the form of β-amyloid (Aβ) deposits occurs not only in Alzheimer's disease (AD) and Down's syndrome (DS) but also as a 'co-pathology' in several disorders including dementia with Lewy bodies (DLB), corticobasal degeneration (CBD), and chronic traumatic encephalopathy (CTE). To determine whether cortical laminar degeneration, as measured by Aβ deposition, is similar in different...
Source: Folia Neuropathologica - Category: Pathology Authors: Tags: Folia Neuropathol Source Type: research
More News: Alzheimer's | Brain | Dementia | Down's Syndrome | Neurology