JAMA Neurology : Nilotinib Effects on Safety, Tolerability, and Potential Biomarkers in Parkinson Disease

Interview with Charbel Moussa, MD, PhD, author of Nilotinib Effects on Safety, Tolerability, and Potential Biomarkers in Parkinson Disease: A Phase 2 Randomized Clinical Trial
Source: JAMA Specialty Journals Author Interviews - Category: General Medicine Source Type: podcasts

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Authors: Argyrou A Abstract Protein folding is considered strongly linked with genetics. The deeper understanding of the mechanisms that allow the folding of proteins is expected to lead to advances in the pharmaceutical sector. The shape of a protein dictates its biological activity, and any exceptions from its natural form can lead to diseases such as Alzheimer's, Parkinson's, and many others. The recent advances in the research of protein folding include computational models for the prediction of protein folding with enough accuracy. In order to understand the process of protein misfolding, a synopsis of the pro...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Salis C, Papageorgiou L, Papakonstantinou E, Hagidimitriou M, Vlachakis D Abstract Neurodegenerative diseases lead to the death of nerve cells in the brain or the spinal cord. A wide range of diseases are included within the group of neurodegenerative disorders, with the most common ones being dementia, Alzheimer's, and Parkinson's diseases. Millions of older people are suffering from such pathologies. The global increase of life expectancy unavoidably leads to a consequent increase in the number of people who will be at some degree affected by neurodegenerative-related diseases. At this moment, there is n...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
In conclusion, quercetin possesses strong iron-chelating abilities and could be recommended as a disease-modifying therapy when administered in combination with L-dopa, early on in the course of Parkinson's disease. PMID: 32468451 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
ConclusionUnderstanding these common links and central topologies under the perspective of systems biology and network theory and greater insights are provided to uncover the complex neurodegeneration processes. PMID: 32468556 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
This article is about "kinesia paradoxa," a phenomenon presented in Parkinson's disease patients who generally suffer from bradykinesia and freezing of gait (FOG) but under certain circumstances exhibit a sudden, brief period of mobility. The objective of this paper was to identify the mechanisms causing this phenomenon, record possible brain circuits involved, and try to locate interconnections between these circuits. Moreover, we are proposing various modeling schemes in order to form the appropriate conditions for experimental design. PMID: 32468533 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Shimada H, Shimada Y Abstract An 86-year-old man, who had undergone a lumboperitoneal shunt for idiopathic normal pressure hydrocephalus (iNPH) implanted 4 years earlier showed progressive parkinsonism for the past year. His clinical symptoms, including resting tremor and rapid eye movement sleep behavior disorder, responsiveness to levodopa, and abnormal findings on 123I-MIBG myocardial scintigraphy and dopamine transporter imaging, indicated that his pathological background of parkinsonism included concomitant synucleinopathy, such as Parkinson's disease or dementia with Lewy bodies, in addition to iNPH....
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Publication date: Available online 29 May 2020Source: Neurología (English Edition)Author(s): F. Valldeoriola, F. Grandas, J.M. Arbelo, M. Blázquez Estrada, M. Calopa Garriga, V.M. Campos-Arillo, P.J. Garcia Ruiz, J.C. Gómez Esteban, C. Leiva Santana, J.C. Martínez Castrillo, P. Mir, A. Salvador Aliaga, F. Vivancos Matellano, R.M. Yáñez Baña
Source: Neurologia - Category: Neurology Source Type: research
Conclusions: The current study indicates that TG infection could improve the cataleptic, asymmetric, nociceptive and behaviors; the level of striatal dopamine release; BDNF levels; TAC; and MDA in PD rats. PMID: 32461971 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Effects of Cardiac Sympathetic Neurodegeneration and PPARγ Activation on Rhesus Macaque Whole Blood miRNA and mRNA Expression Profiles. Biomed Res Int. 2020;2020:9426204 Authors: Metzger JM, Lopez MS, Schmidt JK, Murphy ME, Vemuganti R, Emborg ME Abstract Degeneration of sympathetic innervation of the heart occurs in numerous diseases, including diabetes, idiopathic REM sleep disorder, and Parkinson's disease (PD). In PD, cardiac sympathetic denervation occurs in 80-90% of patients and can begin before the onset of motor symptoms. Today, there are no disease-modifying therapies for cardiac sympa...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
PARKINSON'S disease predominantly affects a certain region in the brain. As the condition gradually becomes apparent, what's the one change in bowel habits that may lead to an earlier diagnosis?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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